OBJECTIVE: To identify biochemical differences in brain tissue between patients with dementia of the Alzheimer type and vascular dementia. DESIGN AND SUBJECTS: Proton magnetic resonance spectroscopy was used to compare 10 patients with dementia of the Alzheimer type and 8 age-matched patients with vascular dementia. RESULTS: The ratios of N-acetyl groups to creatine and N-acetyl groups to choline were lower in regions of subcortical white matter in patients with vascular dementia than in patients with dementia of the Alzheimer type (P < .02). CONCLUSION: Proton magnetic resonance spectroscopy may be useful in distinguishing between dementia of the Alzheimer type and vascular dementia.
OBJECTIVE: To identify biochemical differences in brain tissue between patients with dementia of the Alzheimer type and vascular dementia. DESIGN AND SUBJECTS: Proton magnetic resonance spectroscopy was used to compare 10 patients with dementia of the Alzheimer type and 8 age-matched patients with vascular dementia. RESULTS: The ratios of N-acetyl groups to creatine and N-acetyl groups to choline were lower in regions of subcortical white matter in patients with vascular dementia than in patients with dementia of the Alzheimer type (P < .02). CONCLUSION: Proton magnetic resonance spectroscopy may be useful in distinguishing between dementia of the Alzheimer type and vascular dementia.
Authors: R Barber; P Scheltens; A Gholkar; C Ballard; I McKeith; P Ince; R Perry; J O'Brien Journal: J Neurol Neurosurg Psychiatry Date: 1999-07 Impact factor: 10.154
Authors: A A Capizzano; N Schuff; D L Amend; J L Tanabe; D Norman; A A Maudsley; W Jagust; H C Chui; G Fein; M R Segal; M W Weiner Journal: AJNR Am J Neuroradiol Date: 2000-04 Impact factor: 3.825
Authors: K Kantarci; R C Petersen; B F Boeve; D S Knopman; D F Tang-Wai; P C O'Brien; S D Weigand; S D Edland; G E Smith; R J Ivnik; T J Ferman; E G Tangalos; C R Jack Journal: Neurology Date: 2004-10-26 Impact factor: 9.910
Authors: Jonathan Graff-Radford; Bradley F Boeve; Melissa E Murray; Tanis J Ferman; Nirubol Tosakulwong; Timothy G Lesnick; Mandie Maroney-Smith; Matthew L Senjem; Jeffrey Gunter; Glenn E Smith; David S Knopman; Clifford R Jack; Dennis W Dickson; Ronald C Petersen; Kejal Kantarci Journal: Neurobiol Aging Date: 2014-01-08 Impact factor: 4.673
Authors: N Schuff; A A Capizzano; A T Du; D L Amend; J O'Neill; D Norman; W J Jagust; H C Chui; J H Kramer; B R Reed; B L Miller; K Yaffe; M W Weiner Journal: Neurology Date: 2003-08-12 Impact factor: 9.910
Authors: M T Hu; S D Taylor-Robinson; K R Chaudhuri; J D Bell; R G Morris; C Clough; D J Brooks; N Turjanski Journal: J Neurol Neurosurg Psychiatry Date: 1999-07 Impact factor: 10.154