Intracavernous injection of prostaglandin E1 in spinal cord injured patients with erectile dysfunction. A preliminary report.

Our experience with intracavernous injection of prostaglandin E1 in spinal cord injured patients with neurogenic erectile dysfunction included 15 men. They received testing dosage starting from 5 micrograms with increasing dosage (maximum 20 micrograms) to achieve a rigid erection of Schramek's grade 5 and lasting for at least 20 min. All of them had achieved functional erection adequate for coitus after treatment except one patient who had been proved to have venogenic impotence. We found that intracavernous injection of prostaglandin E1 had significantly improved the erectile condition. No systemic side effect or any other complication was noted except that pain at the injection site was complained of in two patients with incomplete lesion.