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Literature DB >> 8927032

Regulation and control of glucose overutilization in erythrocytes by vanadate.

Abstract

The insulin mimetic effect of vanadate in in vitro incubation of erythrocytes with high glucose concentrations showed an increase in sorbitol accumulation and glucose utilization using U-14C-glucose. Aldose reductase inhibitors and vanadate addition reversed the sorbitol accumulation, whereas insulin could not reverse it. Increased glucose utilization was also normalized with vanadium compounds. Increased activity of aldose reductase and sorbitol levels in diabetic animals were also normalized with vanadate treatment.

Entities: Chemical Disease Gene

Mesh：

Substances：
Vanadates
Glucose

Year: 1995 PMID： 8927032 DOI： 10.1007/bf01075932

Source DB: PubMed Journal: Mol Cell Biochem ISSN： 0300-8177 Impact factor: 3.396

20 in total

1. Hyperglycemia-induced activation of human erythrocyte aldose reductase and alterations in kinetic properties.

Authors: S K Srivastava; N H Ansari; G A Hair; J Jaspan; M B Rao; B Das
Journal: Biochim Biophys Acta Date: 1986-03-28

Review 2. The sorbitol pathway and the complications of diabetes.

Authors: K H Gabbay
Journal: N Engl J Med Date: 1973-04-19 Impact factor: 91.245

Review 3. The biochemistry of the complications of diabetes mellitus.

Authors: M Brownlee; A Cerami
Journal: Annu Rev Biochem Date: 1981 Impact factor: 23.643

4. Vanadate treatment of streptozotocin diabetic rats restores expression of the insulin-responsive glucose transporter in skeletal muscle.

Authors: H V Strout; P P Vicario; C Biswas; R Saperstein; E J Brady; P F Pilch; J Berger
Journal: Endocrinology Date: 1990-05 Impact factor: 4.736

5. Pathways of carbohydrate metabolism in peripheral nervous tissue. I. The contribution of alternative routes of glucose utilization in peripheral nerve and brain.

Authors: J S Hothersall; N Z Baquer; P McLean
Journal: Enzyme Date: 1982

6. Metabolic alterations in the human erythrocyte produced by increases in glucose concentration. The role of the polyol pathway.

Authors: S F Travis; A D Morrison; R S Clements; A I Winegrad; F A Oski
Journal: J Clin Invest Date: 1971-10 Impact factor: 14.808

Regulation and control of glucose overutilization in erythrocytes by vanadate.

1. Hyperglycemia-induced activation of human erythrocyte aldose reductase and alterations in kinetic properties.

Review 2. The sorbitol pathway and the complications of diabetes.

Review 3. The biochemistry of the complications of diabetes mellitus.

4. Vanadate treatment of streptozotocin diabetic rats restores expression of the insulin-responsive glucose transporter in skeletal muscle.

5. Pathways of carbohydrate metabolism in peripheral nervous tissue. I. The contribution of alternative routes of glucose utilization in peripheral nerve and brain.

6. Metabolic alterations in the human erythrocyte produced by increases in glucose concentration. The role of the polyol pathway.

7. Impaired antioxidant status in diabetic rat liver. Effect of vanadate.

8. Insulin like effects of lithium and vanadate on the altered antioxidant status of diabetic rats.

9. Effect of vanadate on elevated blood glucose and depressed cardiac performance of diabetic rats.

10. Sorbinil partially prevents decreased erythrocyte deformability in experimental diabetes mellitus.

1. Protective effects of sodium orthovanadate in diabetic reticulocytes and ageing red blood cells of Wistar rats.