Literature DB >> 8925924

The membrane-bound rat serotonin transporter, SERT1, is an oligomeric protein.

U Jess1, H Betz, P Schloss.   

Abstract

The synaptic actions of the neurotransmitter serotonin are terminated by a selective re-uptake system located in the axonal membrane. To gain information about the quaternary structure of this membrane protein, we transiently expressed the recombinant rat serotonin transporter, SERT1, in human embryonic kidney 293 cells. Treatment with sulfhydryl oxidizing agents and the homobifunctional cross-linker dimethyl suberimidate (DMS) generated adducts of 130-180 kDa and 220-270 kDa, respectively. These data indicate an oligomeric structure of SERT1.

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Year:  1996        PMID： 8925924     DOI： 10.1016/0014-5793(96)00916-7

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  16 in total

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9.  Glycine transporter dimers: evidence for occurrence in the plasma membrane.

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10.  Surface-localized glycine transporters 1 and 2 function as monomeric proteins in Xenopus oocytes.

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