Literature DB >> 8924608

An adduct between peroxynitrite and 2'-deoxyguanosine: 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine.

T Douki1, J Cadet, B N Ames.   

Abstract

The reactivity of peroxynitrite (OONO-) with DNA is of interest because it is is released during chronic inflammation, a major contributor to cancer. Peroxynitrite was found to undergo homolytic addition to the C4-C5 double bond of 2'-deoxyguanosine with formation of 4,5-dihydro-5-hydroxy-4-(nitrosooxy)-2'-deoxyguanosine (nox-dG). This adduct may be a useful marker in the study of the chemical processes associated with the mutagenicity of peroxynitrite.

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Year:  1996        PMID： 8924608     DOI： 10.1021/tx950126n

Source DB:  PubMed          Journal:  Chem Res Toxicol        ISSN： 0893-228X            Impact factor:   3.739


  6 in total

1.  DNA damage by peroxynitrite characterized with DNA repair enzymes.

Authors:  B Epe; D Ballmaier; I Roussyn; K Briviba; H Sies
Journal:  Nucleic Acids Res       Date:  1996-11-01       Impact factor: 16.971

2.  Inflammation and NO(X)-induced nitration: assay for 3-nitrotyrosine by HPLC with electrochemical detection.

Authors:  M K Shigenaga; H H Lee; B C Blount; S Christen; E T Shigeno; H Yip; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1997-04-01       Impact factor: 11.205

3.  Peroxynitrite reaction products of 3',5'-di-O-acetyl-8-oxo-7, 8-dihydro-2'-deoxyguanosine.

Authors:  J C Niles; S Burney; S P Singh; J S Wishnok; S R Tannenbaum
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-12       Impact factor: 11.205

4.  Green Tea Polyphenols for the Protection against Renal Damage Caused by Oxidative Stress.

Authors:  Takako Yokozawa; Jeong Sook Noh; Chan Hum Park
Journal:  Evid Based Complement Alternat Med       Date:  2012-07-10       Impact factor: 2.629

5.  The modified selenenyl amide, M-hydroxy ebselen, attenuates diabetic nephropathy and diabetes-associated atherosclerosis in ApoE/GPx1 double knockout mice.

Authors:  Sih Min Tan; Arpeeta Sharma; Derek Y C Yuen; Nada Stefanovic; Guy Krippner; Govindasamy Mugesh; Zhonglin Chai; Judy B de Haan
Journal:  PLoS One       Date:  2013-07-16       Impact factor: 3.240

6.  Free radicals, oxidative stress, and antioxidants in human health and disease.

Authors:  Okezie I Aruoma
Journal:  J Am Oil Chem Soc       Date:  1998       Impact factor: 1.849
  6 in total

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