Mild mental stress increases insulin sensitivity in healthy young men.

We examined if mental stress alters insulin sensitivity and renal sodium handling in 11 normotensive young men. Following a 60-minute period of equilibration, we performed euglycemic hyperinsulinemic glucose clamp for 150 minutes. The clamp period was divided into three phases; control phase for 90 minutes (I), mental arithmetic phase for 30 minutes (II), and recovery phase for 30 minutes (III). Blood pressure, heart rate and glucose disposal rate (M value) significantly elevated during phase II of the stress study. In a time control study, in which mental arithmetic was not loaded during phase II, blood pressure was kept constant and the changes in M value from phase I to phase II were significantly smaller than those in the stress study. In both studies, fractional excretion of sodium did not significantly change throughout the study period. Thus, insulin sensitivity concerning glucose metabolism increased in response to mild mental stress. However, the effect of insulin on sodium handling was not altered by the stress.