| Literature DB >> 8919642 |
M D Herrera1, A Zarzuelo, J Jiménez, E Marhuenda, J Duarte.
Abstract
1. Flavonoids produced a concentration-dependent relaxation of the contractile responses induced by noradrenaline, KCl, or phorbol 12-myristate-13-acetate in rat aortic rings. Only the flavonoid with three contiguous hydroxyls in B rings (myricetin), at low concentrations, potentiates the contractions evoked by these agonists. 2. The relaxant effects of flavanone on the noradrenaline-induced contractions were potentiated by isoprenaline and those of morin, chrysin, flavanone, and naringenin by sodium nitroprusside. 3. Several mechanisms are implicated in the vasodilatory effects of flavonoids: inhibition of protein kinase C; inhibition of cyclic nucleotide phosphodiesterases; and/or decreased Ca2+ uptake.Entities:
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Year: 1996 PMID： 8919642 DOI： 10.1016/0306-3623(95)02010-1
Source DB: PubMed Journal: Gen Pharmacol ISSN： 0306-3623