Literature DB >> 891878

A cannabinoid with cardiovascular activity but no overt behavioral effects.

M D Adams, J T Earnhardt, B R Martin, L S Harris, W L Dewey, R K Razdan.   

Abstract

Abnormal-delta8-tetrahydrocannabinol (ABN-delta8-THC) failed to elicit central nervous system and cardiovascular effects in laboratory animals. Abnormal-cannabidiol (ABN-CBD) was also devoid of overt behavioral effects but produced marked hypotension with only slight bradycardia in anesthesized dogs.

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Year:  1977        PMID： 891878     DOI： 10.1007/bf01922330

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  7 in total

1.  Pharmacology of some marijuana constituents and 2 heterocyclic analogues.

Authors:  W L Dewey; L S Harris; J F Howes; J S Kennedy; F E Granchelli; H G Pars; R K Razdan
Journal:  Nature       Date:  1970-06-27       Impact factor: 49.962

2.  An intravenous formulation of 9-tetrahydrocannabinol using a non-ionic surfactant.

Authors:  J C Cradock; J P Davignon; C L Litterst; A M Guarino
Journal:  J Pharm Pharmacol       Date:  1973-04       Impact factor: 3.765

3.  Role of the central autonomic nervous system in the hypotension and bradycardia induced by (-)-delta 9-trans-tetrahydrocannabinol.

Authors:  R R Vollmer; I Cavero; R J Ertel; T A Solomon; J P Buckley
Journal:  J Pharm Pharmacol       Date:  1974-03       Impact factor: 3.765

Review 4.  General pharmacological actions of some synthetic tetrahydrocannabinol derivatives.

Authors:  H F Hardman; E F Domino; M H Seevers
Journal:  Pharmacol Rev       Date:  1971-12       Impact factor: 25.468

5.  Marihuana-like activity of new synthetic tetrahydrocannabinols.

Authors:  B R Martin; W L Dewey; L S Harris; J Beckner
Journal:  Pharmacol Biochem Behav       Date:  1975 Sep-Oct       Impact factor: 3.533

6.  Hashish. A simple one-step synthesis of (-)-delta1-tetrahydrocannabinol (THC) from p-mentha-2,8-dien-1-ol and olivetol.

Authors:  R K Razdan; H C Dalzell; G R Handrick
Journal:  J Am Chem Soc       Date:  1974-09-04       Impact factor: 15.419

7.  1-delta9-tetrahydrocannabinol: neurochemical and behavioral effects in the mouse.

Authors:  D Holtzman; R A Lovell; J H Jaffe; D X Freedman
Journal:  Science       Date:  1969-03-28       Impact factor: 47.728
  7 in total
  15 in total

Review 1.  Novel physiologic functions of endocannabinoids as revealed through the use of mutant mice.

Authors:  G Kunos; S Bátkai
Journal:  Neurochem Res       Date:  2001-09       Impact factor: 3.996

Review 2.  Cannabinoids in clinical practice.

Authors:  E M Williamson; F J Evans
Journal:  Drugs       Date:  2000-12       Impact factor: 9.546

3.  CB(1) receptor antagonist SR141716A inhibits Ca(2+)-induced relaxation in CB(1) receptor-deficient mice.

Authors:  Richard D Bukoski; Sándor Bátkai; Zoltán Járai; Yanlin Wang; Laszlo Offertaler; William F Jackson; George Kunos
Journal:  Hypertension       Date:  2002-02       Impact factor: 10.190

4.  Cannabinoid-induced mesenteric vasodilation through an endothelial site distinct from CB1 or CB2 receptors.

Authors:  Z Járai; J A Wagner; K Varga; K D Lake; D R Compton; B R Martin; A M Zimmer; T I Bonner; N E Buckley; E Mezey; R K Razdan; A Zimmer; G Kunos
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-23       Impact factor: 11.205

Review 5.  The endocannabinoid system as an emerging target of pharmacotherapy.

Authors:  Pál Pacher; Sándor Bátkai; George Kunos
Journal:  Pharmacol Rev       Date:  2006-09       Impact factor: 25.468

Review 6.  Cardiovascular pharmacology of cannabinoids.

Authors:  P Pacher; S Bátkai; G Kunos
Journal:  Handb Exp Pharmacol       Date:  2005

7.  Vasodilator actions of abnormal-cannabidiol in rat isolated small mesenteric artery.

Authors:  W-S Vanessa Ho; C Robin Hiley
Journal:  Br J Pharmacol       Date:  2003-04       Impact factor: 8.739

8.  Mechanisms involved in oleamide-induced vasorelaxation in rat mesenteric resistance arteries.

Authors:  Varadarajan Sudhahar; Sean Shaw; John D Imig
Journal:  Eur J Pharmacol       Date:  2009-04-01       Impact factor: 4.432

9.  The novel endocannabinoid receptor GPR55 is activated by atypical cannabinoids but does not mediate their vasodilator effects.

Authors:  D G Johns; D J Behm; D J Walker; Z Ao; E M Shapland; D A Daniels; M Riddick; S Dowell; P C Staton; P Green; U Shabon; W Bao; N Aiyar; T-L Yue; A J Brown; A D Morrison; S A Douglas
Journal:  Br J Pharmacol       Date:  2007-08-20       Impact factor: 8.739

10.  Histamine release in dogs by Emulphor EL620.

Authors:  J W Constantine; W S Lebel
Journal:  Experientia       Date:  1979-03-15
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