Literature DB >> 891876

Methiothepin and a 5-HT pathway to rat substantia nigra.

A Dray, N R Oakley.   

Abstract

Methiothepin reduced both median-raphe evoked and exogenous 5-HT depression of single substantia nigra neurones. While this is compatible with a serotonin releasing pathway, additional interactions of methiothepin with exogenous dopamine suggest the need for further pharmacological confirmation.

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Year:  1977        PMID： 891876     DOI： 10.1007/bf01922326

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  6 in total

1.  Antagonism of 5-hydroxytryptamine by methiothepin shown in microelectrophoretic studies of neurones in the lateral geniculate nucleus.

Authors:  A K Tebecis
Journal:  Nat New Biol       Date:  1972-07-12

2.  The mechanism by which methiothepin, a putative serotonin receptor antagonist, icnreses brain 5-hydroxyindole levels.

Authors:  J H Jacoby; H Shabshelowitz; J D Fernstrom; R J Wurtman
Journal:  J Pharmacol Exp Ther       Date:  1975-11       Impact factor: 4.030

3.  Caudate stimulation and substantia nigra activity in the rat.

Authors:  A Dray; T J Gonye; N R Oakley
Journal:  J Physiol       Date:  1976-08       Impact factor: 5.182

4.  Blockade of central 5-hydroxytryptamine receptors by methiothepin.

Authors:  M A Monachon; W P Burkard; M Jalfre; W Haefely
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1972       Impact factor: 3.000

5.  Methiothepin elevation of 5-hydroxyindoleacetic acid levels in various anatomic regions of rat brain.

Authors:  R W Fuller; K W Perry
Journal:  Brain Res       Date:  1974-04-19       Impact factor: 3.252

6.  Evidence for the existence of a raphe projection to the substantia nigra in rat.

Authors:  A Dray; T J Gonye; N R Oakley; T Tanner
Journal:  Brain Res       Date:  1976-08-20       Impact factor: 3.252
  6 in total
  1 in total

1.  Blockade of Intranigral and Systemic D3 Receptors Stimulates Motor Activity in the Rat Promoting a Reciprocal Interaction among Glutamate, Dopamine, and GABA.

Authors:  Marina Rodríguez-Sánchez; Rodrigo Erick Escartín-Pérez; Gerardo Leyva-Gómez; José Arturo Avalos-Fuentes; Francisco Javier Paz-Bermúdez; Santiago Iván Loya-López; Jorge Aceves; David Erlij; Hernán Cortés; Benjamín Florán
Journal:  Biomolecules       Date:  2019-09-20
  1 in total

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