Literature DB >> 8918551

African swine fever virus gene A179L, a viral homologue of bcl-2, protects cells from programmed cell death.

A Brun1, C Rivas, M Esteban, J M Escribano, C Alonso.   

Abstract

The African swine fever virus (ASFV) open reading frame A179L, which is similar to the human proto-oncogene bcl-2, has been cloned and expressed in vaccinia virus under control of the pEIL synthetic early/late promoter. The A179L gene product prevented cell death in HeLa and BSC-40 cells doubly infected with another recombinant vaccinia virus expressing the interferon-induced double-stranded RNA-activated protein kinase (p68 kinase), which activates a rapid cell death characteristic of apoptosis. This finding suggests that the A179L gene has a function similar to that of bcl-2 in preventing apoptosis and may play an important role during productive ASFV infection.

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Year:  1996        PMID： 8918551     DOI： 10.1006/viro.1996.0592

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  41 in total

1.  Induction of apoptosis by double-stranded-RNA-dependent protein kinase (PKR) involves the alpha subunit of eukaryotic translation initiation factor 2 and NF-kappaB.

Authors:  J Gil; J Alcamí; M Esteban
Journal:  Mol Cell Biol       Date:  1999-07       Impact factor: 4.272

2.  The pp38 gene of Marek's disease virus (MDV) is necessary for cytolytic infection of B cells and maintenance of the transformed state but not for cytolytic infection of the feather follicle epithelium and horizontal spread of MDV.

Authors:  I M Gimeno; R L Witter; H D Hunt; S M Reddy; L F Lee; R F Silva
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

3.  Novel swine virulence determinant in the left variable region of the African swine fever virus genome.

Authors:  J G Neilan; L Zsak; Z Lu; G F Kutish; C L Afonso; D L Rock
Journal:  J Virol       Date:  2002-04       Impact factor: 5.103

Review 4.  Diverse mechanisms evolved by DNA viruses to inhibit early host defenses.

Authors:  Marni S Crow; Krystal K Lum; Xinlei Sheng; Bokai Song; Ileana M Cristea
Journal:  Crit Rev Biochem Mol Biol       Date:  2016-09-21       Impact factor: 8.250

5.  Vaccinia virus infection disarms the mitochondrion-mediated pathway of the apoptotic cascade by modulating the permeability transition pore.

Authors:  S T Wasilenko; A F Meyers; K Vander Helm; M Barry
Journal:  J Virol       Date:  2001-12       Impact factor: 5.103

6.  African swine fever virus protein p54 interacts with the microtubular motor complex through direct binding to light-chain dynein.

Authors:  C Alonso; J Miskin; B Hernáez; P Fernandez-Zapatero; L Soto; C Cantó; I Rodríguez-Crespo; L Dixon; J M Escribano
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

7.  A comparative analysis on the synonymous codon usage pattern in viral functional genes and their translational initiation region of ASFV.

Authors:  Jian-Hua Zhou; Zong-Liang Gao; Dong-Jie Sun; Yao-Zhong Ding; Jie Zhang; Laszlo Stipkovits; Susan Szathmary; Zygmunt Pejsak; Yong-Sheng Liu
Journal:  Virus Genes       Date:  2012-11-16       Impact factor: 2.332

8.  Epstein-Barr virus encodes a novel homolog of the bcl-2 oncogene that inhibits apoptosis and associates with Bax and Bak.

Authors:  W L Marshall; C Yim; E Gustafson; T Graf; D R Sage; K Hanify; L Williams; J Fingeroth; R W Finberg
Journal:  J Virol       Date:  1999-06       Impact factor: 5.103

9.  The subcellular distribution of multigene family 110 proteins of African swine fever virus is determined by differences in C-terminal KDEL endoplasmic reticulum retention motifs.

Authors:  Christopher Netherton; Isabelle Rouiller; Thomas Wileman
Journal:  J Virol       Date:  2004-04       Impact factor: 5.103

10.  Functionality and cell anchorage dependence of the African swine fever virus gene A179L, a viral bcl-2 homolog, in insect cells.

Authors:  A Brun; F Rodríguez; J M Escribano; C Alonso
Journal:  J Virol       Date:  1998-12       Impact factor: 5.103
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