Literature DB >> 891820

Metabolic rearrangement of fluorenone oxime to phenanthridinone.

L Sternson, F Hincal.   

Abstract

Fluorenone oxime is metabolized in vivo in the rat to phenanthrifinone which is excreted in the urine. The structure of the metabolite has been determined by comparison of chromatographic and spectral properties of the metabolites with authentic phenanthridinone.

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Year:  1977        PMID： 891820     DOI： 10.1007/bf01945981

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  Metabolism of amphetamine and beta,beta-difluoroamphetamine in phenobarbital-treated rats.

Authors:  R W Fuller; C J Parli; B B Molloy
Journal:  Biochem Pharmacol       Date:  1973-08-15       Impact factor: 5.858

2.  Phenylacetone oxime--an intermediate in the oxidative deamination of amphetamine.

Authors:  H B Hucker; B M Michniewicz; R E Rhodes
Journal:  Biochem Pharmacol       Date:  1971-08       Impact factor: 5.858

3.  Derivatives of fluorene. XXX. Rearrangement and antitumor activities of some 9-oxofluorene oximes. 6(5H)-Phenanthridinones. I.

Authors:  H L Pan; T L Fletcher
Journal:  J Med Chem       Date:  1969-09       Impact factor: 7.446

4.  The mechanism of microsomal deamination: heavy isotope studies.

Authors:  C J Parli; R E McMahon
Journal:  Drug Metab Dispos       Date:  1973 Jan-Feb       Impact factor: 3.922

5.  Phenylacetone oxime--an intermediate in amphetamine deamination.

Authors:  H B Hucker
Journal:  Drug Metab Dispos       Date:  1973 Jan-Feb       Impact factor: 3.922

6.  The metabolism of acetophenone oxime in rat liver homogenates.

Authors:  J Hes; L A Sternson
Journal:  Drug Metab Dispos       Date:  1974 Jul-Aug       Impact factor: 3.922

Review 7.  Metabolic activation of N-hydroxy compounds by conjugation.

Authors:  C C Irving
Journal:  Xenobiotica       Date:  1971 Jul-Oct       Impact factor: 1.908

8.  Species variations in the metabolism of acetophenone oxime by hepatic enzymes.

Authors:  L A Sternson; J Hes
Journal:  Pharmacology       Date:  1975       Impact factor: 2.547
  8 in total

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