Literature DB >> 891781

Comparison of bicyclic phosphorous esters with bicuculline and picrotoxin as antagonists of presynaptic inhibition in the rat cuneate nucleus.

N Davidson, E I Macfarlane, D L Michie.   

Abstract

The effects of 2 of a series of bicyclic phosphorous esters, the ethyl (EPTBO) and isopropyl (IPTBO) compounds, were compared with those of the GABA antagonists, picrotoxin and bicuculline, on presynaptic inhibition in the rat cunneate nucleus. Both EPTBO and IPTBO were found to be effective, reversible antagonists of presynaptic inhibition, with IPTBO approximately 10 times more potent than EPTBO and equipotent with bicuculline, EPTBO equipotent with picrotoxin.

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Year:  1977        PMID： 891781     DOI： 10.1007/bf01951291

Source DB:  PubMed          Journal:  Experientia        ISSN： 0014-4754


  8 in total

1.  PHARMACOLOGICAL STUDIES ON THE PRIMARY AFFERENT DEPOLARIZATION OF THE TOAD SPINAL CORD.

Authors:  R F SCHMIDT
Journal:  Pflugers Arch Gesamte Physiol Menschen Tiere       Date:  1963-07-02

2.  PHARMACOLOGICAL STUDIES ON PRESYNAPTIC INHIBITION.

Authors:  J C ECCLES; R SCHMIDT; W D WILLIS
Journal:  J Physiol       Date:  1963-10       Impact factor: 5.182

3.  Bicyclic phosphorus esters that are potent convulsants and GABA antagonists.

Authors:  N G Bowery; J F Collins; R G Hill
Journal:  Nature       Date:  1976-06-17       Impact factor: 49.962

4.  The effect of the GABA antagonists bicuculline and picrotoxin on primary afferent terminal excitability.

Authors:  R A Levy; E G Anderson
Journal:  Brain Res       Date:  1972-08-11       Impact factor: 3.252

5.  The effects of bicuculline on the isolated spinal cord of the frog.

Authors:  R A Davidoff
Journal:  Exp Neurol       Date:  1972-04       Impact factor: 5.330

6.  Presynaptic inhibition in cuneate blocked by GABA antagonists.

Authors:  N Davidson; H Reisine
Journal:  Nat New Biol       Date:  1971-09-15

7.  The effects of depleting GABA on cuneate presynaptic inhibition.

Authors:  N R Banna; S J Jabbur
Journal:  Brain Res       Date:  1971-10-29       Impact factor: 3.252

8.  Amino acids and presynaptic inhibition in the rat cuneate nucleus.

Authors:  N Davidson; C A Southwick
Journal:  J Physiol       Date:  1971-12       Impact factor: 5.182
  8 in total
  1 in total

1.  Evidence for a neuronal release of isotopically labelled gamma-amino-n-butyric acid (GABA) from the rat dorsal medulla in vivo.

Authors:  J A Assumpção; N Bernardi; C G Dacke; N Davidson
Journal:  Experientia       Date:  1979-02-15
  1 in total

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