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Literature DB >> 8917596

Heteromultimeric CLC chloride channels with novel properties.

Abstract

The skeletal muscle chloride channel CLC-1 and the ubiquitous volume-activated chloride channel CLC-2 belong to a large gene family whose members often show overlapping expression patterns. CLC-1 and CLC-2 are coexpressed in skeletal and smooth muscle and in the heart. By coexpressing CLC-1 and CLC-2 in Xenopus oocytes, we now show the formation of novel CLC-1/CLC-2 heterooligomers that yield time-independent linear chloride currents with a chloride-->bromide-->iodide selectivity sequence. Formation of heterooligomeric CLC channels increases the number and possible functions of chloride channels.

Entities: Chemical Gene Species

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Year: 1996 PMID： 8917596 PMCID： PMC24098 DOI： 10.1073/pnas.93.23.13362

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

44 in total

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90 in total

1. Deceleration of the E1P-E2P transition and ion transport by mutation of potentially salt bridge-forming residues Lys-791 and Glu-820 in gastric H+/K+-ATPase.

Authors: Katharina L Dürr; Ina Seuffert; Thomas Friedrich
Journal: J Biol Chem Date: 2010-10-04 Impact factor: 5.157

2. The first-nucleotide binding domain of the cystic-fibrosis transmembrane conductance regulator is important for inhibition of the epithelial Na+ channel.

Authors: R Schreiber; A Hopf; M Mall; R Greger; K Kunzelmann
Journal: Proc Natl Acad Sci U S A Date: 1999-04-27 Impact factor: 11.205

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Authors: Ben Corry; Megan O'Mara; Shin-Ho Chung
Journal: Biophys J Date: 2004-02 Impact factor: 4.033

4. Conformational dynamics of the Na+/K+-ATPase probed by voltage clamp fluorometry.

Authors: Sven Geibel; Jack H Kaplan; Ernst Bamberg; Thomas Friedrich
Journal: Proc Natl Acad Sci U S A Date: 2003-01-27 Impact factor: 11.205

5. KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents.

Authors: Niels Decher; Florian Bundis; Rolf Vajna; Klaus Steinmeyer
Journal: Pflugers Arch Date: 2003-07-10 Impact factor: 3.657

6. Receptor for activated C kinase 1 (RACK1) inhibits function of transient receptor potential (TRP)-type channel Pkd2L1 through physical interaction.

Authors: Jungwoo Yang; Qian Wang; Wang Zheng; Jagdeep Tuli; Qiang Li; Yuliang Wu; Shaimaa Hussein; Xiao-Qing Dai; Shiva Shafiei; Xiao-Gai Li; Patrick Y Shen; Jian-Cheng Tu; Xing-Zhen Chen
Journal: J Biol Chem Date: 2011-12-15 Impact factor: 5.157

10. Inhibition of the Na/bicarbonate cotransporter NBCe1-A by diBAC oxonol dyes relative to niflumic acid and a stilbene.

Authors: Xiaofen Liu; Jennifer B Williams; Brandon R Sumpter; Mark O Bevensee
Journal: J Membr Biol Date: 2007-06-20 Impact factor: 1.843