Literature DB >> 8917110

Alternate splice-site utilization in the gene for the catalytic subunit of the DNA-activated protein kinase, DNA-PKcs.

M A Connelly1, H Zhang, J Kieleczawa, C W Anderson.   

Abstract

Analysis of polyA-selected RNAs and cDNA clones from several human cell lines revealed the presence of a 93-bp exon in the PI kinase homology region of DNA-PKcs that was not present in the cDNA sequence derived from HeLa cell cDNA clones. RT-PCR showed that most DNA-PKcs mRNAs in human cells have this exon. Thus, the nascent DNA-PKcs polypeptide is composed of 4127 aa and has a predicted mol. wt. of 469021 (470 kDa).

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Year:  1996        PMID： 8917110     DOI： 10.1016/0378-1119(96)00135-7

Source DB:  PubMed          Journal:  Gene        ISSN： 0378-1119            Impact factor:   3.688


  6 in total

1.  Inhibition of homologous recombination by variants of the catalytic subunit of the DNA-dependent protein kinase (DNA-PKcs).

Authors:  Erin Convery; Euy Kyun Shin; Qi Ding; Wei Wang; Pauline Douglas; Laurie S Davis; Jac A Nickoloff; Susan P Lees-Miller; Katheryn Meek
Journal:  Proc Natl Acad Sci U S A       Date:  2005-01-24       Impact factor: 11.205

Review 2.  Interaction of Ku protein and DNA-dependent protein kinase catalytic subunit with nucleic acids.

Authors:  W S Dynan; S Yoo
Journal:  Nucleic Acids Res       Date:  1998-04-01       Impact factor: 16.971

3.  Requirement for the kinase activity of human DNA-dependent protein kinase catalytic subunit in DNA strand break rejoining.

Authors:  A Kurimasa; S Kumano; N V Boubnov; M D Story; C S Tung; S R Peterson; D J Chen
Journal:  Mol Cell Biol       Date:  1999-05       Impact factor: 4.272

4.  Functional significance for a heterogenous ribonucleoprotein A18 signature RNA motif in the 3'-untranslated region of ataxia telangiectasia mutated and Rad3-related (ATR) transcript.

Authors:  Ruiqing Yang; Ming Zhan; Narasimha Rao Nalabothula; Qingyuan Yang; Fred E Indig; France Carrier
Journal:  J Biol Chem       Date:  2010-01-26       Impact factor: 5.157

5.  A microarray configuration to quantify expression levels and relative abundance of splice variants.

Authors:  Pascale Fehlbaum; Caroline Guihal; Laurent Bracco; Olivier Cochet
Journal:  Nucleic Acids Res       Date:  2005-03-10       Impact factor: 16.971

6.  Combined deficiency of Senataxin and DNA-PKcs causes DNA damage accumulation and neurodegeneration in spinal muscular atrophy.

Authors:  Annapoorna Kannan; Kanchan Bhatia; Dana Branzei; Laxman Gangwani
Journal:  Nucleic Acids Res       Date:  2018-09-19       Impact factor: 16.971
  6 in total

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