Potentiation of d-tubocurarine (d-Tc) neuromuscular blockade in cats by lithium chloride.

I.v. infusion of LiCl at 1.0 mEq/0.25 ml/min produced significant decrease in plasma Na+ from 158 +/- 4.5 mEq/l (p less than 0.025) and in Ca2+ from 7.8 +/- 0.34 to 6.8 +/- 0.24 mg% (p less than 0.01) with insignificant increase in K+. No significant changes in plasma electrolytes were observed on infusion of NaCl. The d-Tc induced neuromuscular blockade in Li Cl infused animals was significantly greater than that in Na Cl infused ones.