| Literature DB >> 8916101 |
M J Arranz1, D A Collier, J Munro, P Sham, G Kirov, M Sodhi, G Roberts, J Price, R W Kerwin.
Abstract
Clozapine is an atypical antipsychotic with affinity for a broad range of receptors, including serotonin (5-HT) and dopamine receptors. It is successful in treating about 60% of patients refractory to other antipsychotic drugs. Since genetic variation in clozapine's neurotransmitter receptor targets may affect clinical response through altering drug binding or receptor expression, we have studied a His452Tyr polymorphism in the 5-HT2A receptor (HTR2A) in a sample of 153 schizophrenic patients undergoing clozapine treatment and 178 normal controls. An association was found between the allele Tyr452 and poor clinical response.Entities:
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Year: 1996 PMID： 8916101
Source DB: PubMed Journal: Neurosci Lett ISSN： 0304-3940 Impact factor: 3.046