| Literature DB >> 891604 |
G Assouline, V Leibson, A Danon.
Abstract
A whole-cell preparation of rat stomach put out appreciable amounts of immunoassayable PGE. Buffers made hypertonic with either sodium chloride or mannitol effected several-fold increases in PGE output, while a comparable osmotic concentration of urea seemed to produce much less stimulation. Enhancement of PGE output by saline--hypertonic buffers was concentration-dependent. It is suggested that the osmolarity of the gastric contents may play a role in regulating gastric PG biosynthesis.Entities:
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Year: 1977 PMID： 891604 DOI： 10.1016/0014-2999(77)90073-5
Source DB: PubMed Journal: Eur J Pharmacol ISSN： 0014-2999 Impact factor: 4.432