Comparative pharmacokinetics and tissue distribution of norfloxacin-glycine acetate in flounder, (Paralichthys olivaceus) at two different temperatures.

The pharmacokinetics of norfloxacin-glycine acetate (NFXGA), a newly formulated norfloxacin, was investigated in healthy flounders at two different seawater temperature (at 12 degrees C and 20 degrees C) varying concentrations (100 ppm and 10 ppm), using dipping administration. It was shown that the elimination half-life (T1/2) of norfloxacin at 20 degrees C (10 ppm: 13.95 +/- 1.18 hr, 100 ppm: 11.71 +/- 1.32 hr) was significantly shorter than that at 12 degrees C (10 ppm: 16.61 +/- 1.47 hr, 100 ppm: 16.32 +/- 1.19 hr) in flounders. Mean residence time (MRT) was calculated at 12 degrees C (10 ppm: 194.87 +/- 29.88 hr, 100 ppm: 1,222.37 +/- 161.45 hr) and 20 degrees C (10 ppm: 168.42 +/- 25.85, 100 ppm: 606.14 +/- 122.75 hr). Meanwhile, in the flounder tissue distribution of norfloxacin. It was shown that serum, muscle, kidney, and liver exhibited different elimination half-lives of norfloxacin.