Biochemical changes in fowl serum during infection with Salmonella typhimurium.

Two groups of White Leghorns were inoculated with Salmonella Typhimurium in the breast muscle. One group was injected with amikacin every 9 hr (8 times) from 24 to 96 hr after the bacterial inoculation and the other group was given no amikacin. In both groups, a significant increase in the levels of aspartate aminotransferase and creatine kinase, and a significant decrease in the levels of alkaline phosphatase, total cholesterol and glucose were found 96 hr after inoculation. There were, however, no significant differences in the blood chemical values between the amikacin-treated group and non-treated group. The results from the present study may provide basic data for further investigation of blood chemical values during Salmonella infection and amikacin therapy in fowls.