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Literature DB >> 891591

Binding of 16alpha-gitoxin and its 16-acetate to human serum albumin.

Abstract

The binding of semi-synthetic (16alpha-gitoxin and its 16-acetate) and naturally occurring cardioactive glycosides (digitoxin, ouabain) to human serum albumin was studied using equilibrium dialysis, ultracentrifugation and gel filtration. 16alpha-gitoxin was 75% bound and its 16-acetate 95%. The percentage binding of digitoxin and ouabain was in good agreement with values reported in literature.

Entities: Chemical Gene Species

Mesh：

Substances：

Year: 1977 PMID： 891591 DOI： 10.1007/bf00562939

Source DB: PubMed Journal: Eur J Clin Pharmacol ISSN： 0031-6970 Impact factor: 2.953

9 in total

1. Absorption and metabolism in man of 16-epi-gitoxin, a new semi-synthetic cardioactive glycoside.

Authors: K O Haustein
Journal: Eur J Clin Pharmacol Date: 1977-07-19 Impact factor: 2.953

2. On physical forces governing cardiac glycoside activity.

Authors: K R Repke; F Dittrich; P Berlin; H J Portius
Journal: Ann N Y Acad Sci Date: 1974 Impact factor: 5.691

3. Ouabain pharmacokinetics in dog and man. Determination by radioimmunoassay.

Authors: R Selden; T W Smith
Journal: Circulation Date: 1972-06 Impact factor: 29.690

4. [Quantitative determination of protein binding of drugs by gel filtration].

Authors: J Krieglstein; G Kuschinsky
Journal: Arzneimittelforschung Date: 1968-03

5. Different relationships between therapeutic and toxic actions of 16-epi-gitoxin, gitoxin and ouabain on isolated cardiac preparations.

Authors: K O Haustein; F Markwardt; K R Repke
Journal: Eur J Pharmacol Date: 1970-04 Impact factor: 4.432

6. Plasma protein binding of digitoxin and digoxin in several mammalian species.

Authors: J D Baggot; L E Davis
Journal: Res Vet Sci Date: 1973-07 Impact factor: 2.534

7. [Binding of sulfonamides to protein. 6. Determination of protein binding of sulfonamides by means of ultracentrifuge and gel filtration].

Authors: W Scholtan
Journal: Arzneimittelforschung Date: 1965-12

8. [Determination of protein binding of digitalis preparations by means of the ultracentrifuge].

Authors: W Scholtan; K Schlossmann; H Rosenkranz
Journal: Arzneimittelforschung Date: 1966-02

9. Different toxic effects of ouabain and 16-epi-gitoxin on Purkinje fibres and ventricular muscle fibres.

Authors: G Nowak; K O Haustein
Journal: Pharmacology Date: 1976 Impact factor: 2.547