Literature DB >> 8915646

Lack of postdiscectomy adhesions following application of ADCON-L: a case report.

N de Tribolet1, J T Robertson.   

Abstract

STUDY
DESIGN: This case study focused on findings in two patients who underwent repeat discectomy following reherniation.
OBJECTIVES: The cases are presented to show that use of ADCON-L Anti-Adhesion Barrier Gel can limit the extent of peridural adhesions subsequent to discectomy. Peridural fibrosis has been implicated as one of the principal causes of failed back surgery syndrome following lumbar discectomy. SUMMARY OF BACKGROUND DATA: Accurate assessment of the extent of scarring following lumbar discectomy has been made possible by the use of MR1; however, the only direct means of assessing adhesions is during reoperations to treat reherniations or other causes of surgical failure.
METHODS: Both of the initial operations were performed using standard microsurgical procedures. At the end of surgery, one patient received ADCON-L Anti-Adhesion Barrier Gel and the other did not.
RESULTS: During the repeat operation, extensive peridural adhesions were found in the patient who did not receive ADCON-L during the initial discectomy procedure. In contrast, essentially neither scar nor adhesions were found in the patient who received ADCON-L.
CONCLUSION: ADCON-L effectively inhibits the development of peridural fibrosis following lumbar discectomy. This finding could have implications for the rate of occurrence of failed back surgery syndrome.

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Year:  1996        PMID: 8915646     DOI: 10.1007/bf00298568

Source DB:  PubMed          Journal:  Eur Spine J        ISSN: 0940-6719            Impact factor:   3.134


  9 in total

1.  Association between peridural scar and recurrent radicular pain after lumbar discectomy: magnetic resonance evaluation. ADCON-L European Study Group.

Authors:  J S Ross; J T Robertson; R C Frederickson; J L Petrie; N Obuchowski; M T Modic; N deTribolet
Journal:  Neurosurgery       Date:  1996-04       Impact factor: 4.654

2.  Surgery for herniated lumbar discs: a literature synthesis.

Authors:  R M Hoffman; K J Wheeler; R A Deyo
Journal:  J Gen Intern Med       Date:  1993-09       Impact factor: 5.128

3.  Prevention of nerve root adhesions after laminectomy.

Authors:  K Yong-Hing; J Reilly; V de Korompay; W H Kirkaldy-Willis
Journal:  Spine (Phila Pa 1976)       Date:  1980 Jan-Feb       Impact factor: 3.468

4.  Use of ADCON-L to inhibit postoperative peridural fibrosis and related symptoms following lumbar disc surgery: a preliminary report.

Authors:  J L Petrie; J S Ross
Journal:  Eur Spine J       Date:  1996       Impact factor: 3.134

5.  Causes of failure of surgery on the lumbar spine.

Authors:  C V Burton; W H Kirkaldy-Willis; K Yong-Hing; K B Heithoff
Journal:  Clin Orthop Relat Res       Date:  1981-06       Impact factor: 4.176

6.  The reduction of postlaminectomy peridural fibrosis in rabbits by a carbohydrate polymer.

Authors:  J T Robertson; A L Meric; F C Dohan; J B Schweitzer; J R Wujek; S Ahmad
Journal:  J Neurosurg       Date:  1993-07       Impact factor: 5.115

7.  A long-term outcome analysis of 984 surgically treated herniated lumbar discs.

Authors:  R A Davis
Journal:  J Neurosurg       Date:  1994-03       Impact factor: 5.115

8.  A carbohydrate polymer that effectively prevents epidural fibrosis at laminectomy sites in the rat.

Authors:  J R Wujek; S Ahmad; A Harel; K H Maier; D Roufa; J Silver
Journal:  Exp Neurol       Date:  1991-11       Impact factor: 5.330

9.  Postoperative lumbar epiduro-arachnoiditis. Diagnostic and therapeutic aspects.

Authors:  M Benoist; C Ficat; P Baraf; J Cauchoix
Journal:  Spine (Phila Pa 1976)       Date:  1980 Sep-Oct       Impact factor: 3.468

  9 in total
  1 in total

1.  ADCON-L symposium. Round table discussion.

Authors:  J T Robertson; J L Petrie; R C Frederickson; N de Tribolet; R Hardy
Journal:  Eur Spine J       Date:  1996       Impact factor: 3.134

  1 in total

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