Literature DB >> 8915644

ADCON-L: a review of its development, mechanism of action, and preclinical data.

R C Frederickson1.   

Abstract

ADCON-L Anti-Adhesion Barrier Gel is a resorbable gel that is placed into the site of a laminectomy before surgical closure and acts as a barrier to scar and surgical adhesions. The scientific rationale for ADCON products is based on certain properties of glial cells and the nature and role of the basal lamina. ADCON-L was evaluated in laminectomy models using rats and rabbits and a discectomy model in dogs. In all studies, ADCON-L was an effective barrier to peridural scar and surgical adhesions.

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Year:  1996        PMID： 8915644     DOI： 10.1007/bf00298566

Source DB:  PubMed          Journal:  Eur Spine J        ISSN： 0940-6719            Impact factor:   3.134


  5 in total

Review 1.  The glial scar: its bearing on axonal elongation and transplantation approaches to CNS repair.

Authors:  P J Reier; J D Houle
Journal:  Adv Neurol       Date:  1988

2.  Prevention of nerve root adhesions after laminectomy.

Authors:  K Yong-Hing; J Reilly; V de Korompay; W H Kirkaldy-Willis
Journal:  Spine (Phila Pa 1976)       Date:  1980 Jan-Feb       Impact factor: 3.468

3.  Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro.

Authors:  D M Snow; V Lemmon; D A Carrino; A I Caplan; J Silver
Journal:  Exp Neurol       Date:  1990-07       Impact factor: 5.330

4.  The reduction of postlaminectomy peridural fibrosis in rabbits by a carbohydrate polymer.

Authors:  J T Robertson; A L Meric; F C Dohan; J B Schweitzer; J R Wujek; S Ahmad
Journal:  J Neurosurg       Date:  1993-07       Impact factor: 5.115

5.  A carbohydrate polymer that effectively prevents epidural fibrosis at laminectomy sites in the rat.

Authors:  J R Wujek; S Ahmad; A Harel; K H Maier; D Roufa; J Silver
Journal:  Exp Neurol       Date:  1991-11       Impact factor: 5.330
  5 in total
  3 in total

1.  Preparation and characterization of a new gellan gum and sulphated hyaluronic acid hydrogel designed for epidural scar prevention.

Authors:  Claudia Cencetti; Davide Bellini; Cristina Longinotti; Andrea Martinelli; Pietro Matricardi
Journal:  J Mater Sci Mater Med       Date:  2011-01-08       Impact factor: 3.896

2.  Inhibition of spinal fusion by use of a tissue ingrowth inhibitor.

Authors:  Xuenong Zou; Haisheng Li; Niels Egund; Martin Lind; Cody Bünger
Journal:  Eur Spine J       Date:  2003-11-14       Impact factor: 3.134

3.  The histopathological effects of reabsorbable polyethylene glycol hydrogel (Coseal) on epidural fibrosis in an experimental postlaminectomy model in rats

Authors:  Emrah Keskin; Hasan Ali Aydın; Murat Kalaycı; Emre Işık; Utku Özgen; Kenan Şimşek; Deniz Baklacı; Mertol Gökçe
Journal:  Turk J Med Sci       Date:  2021-06-28       Impact factor: 0.973
  3 in total

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