Literature DB >> 891555

Quantitative analysis of the distribution of 99mTc-labelled ethylene hydroxy diphosphonate in young rats.

M Rohlin, B Nosslin.   

Abstract

The distribution of 99mTc-labelled ethylene 1-hydroxy-1,1-diphosphonate (EHDP) in young rats was studied 1, 3, 6 and 9 h after intraperitoneal injection. The concentration of 99mTc in bone was 8-10 times higher than that in the kidneys and 20-1000 times higher than those in other soft tissues. The concentration in bone remained constant throughout the observation time. In some of the animals sacrificed after 3, 6, or 9 h the uptake in the liver and spleen was higher than that found in the majority of the animals.

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Year:  1977        PMID： 891555     DOI： 10.1007/bf00253683

Source DB:  PubMed          Journal:  Eur J Nucl Med        ISSN： 0340-6997


  9 in total

1.  Distribution of 99mTc-Sn diphosphonate and free 99mTc-pertechnetate in selected soft and hard tissues.

Authors:  E B Silberstein; M D Francis; A J Tofe; C L Slough
Journal:  J Nucl Med       Date:  1975-01       Impact factor: 10.057

2.  [Comparative animal experiments concerning the distribution of 99mTc-pyrophosphate, 99mTc-diphosphonate and 85Sr (author's transl)].

Authors:  U Büll; D Balser; K W Frey
Journal:  Fortschr Geb Rontgenstr Nuklearmed       Date:  1974-04

3.  Optimization of the ratio of stannous tin: ethane-1-hydroxy-1, 1-diphosphonate for bone scanning with 99mTc-pertechnetate.

Authors:  A J Tofe; M D Francis
Journal:  J Nucl Med       Date:  1974-02       Impact factor: 10.057

4.  New bone scanning agent: 99m Tc-labeled 1-hydroxy-ethylidene-1, 1-disodium phosphonate.

Authors:  F P Castronovo; R J Callahan
Journal:  J Nucl Med       Date:  1972-11       Impact factor: 10.057

5.  A new complex of 99mTc for skeletal imaging.

Authors:  G Subramanian; J G McAfee
Journal:  Radiology       Date:  1971-04       Impact factor: 11.105

6.  99m Tc-EHDP: a potential radiopharmaceutical for skeletal imaging.

Authors:  G Subramanian; J G McAfee; R J Blair; A Mehter; T Connor
Journal:  J Nucl Med       Date:  1972-12       Impact factor: 10.057

7.  A "kit" method for the preparation of a technetium-tin(II) colloid and a study of its properties.

Authors:  M S Lin; H S Winchell
Journal:  J Nucl Med       Date:  1972-01       Impact factor: 10.057

8.  Whole-body autoradiography of 99Tcm-labelled ethylene-1-hydroxy-1, 1-diphosphonate (EHDP) in young rats.

Authors:  M Rohlin
Journal:  Acta Radiol Ther Phys Biol       Date:  1976-10

9.  Chemistry of technetium radiopharmaceuticals. I. Exploration of the tissue distribution and oxidation state consequences of technetium (IV) in Tc-Sn-gluconate and Tc-Sn-EHDP using carrier 99Tc.

Authors:  P Hambright; J McRae; P E Valk; A J Bearden; B A Shipley
Journal:  J Nucl Med       Date:  1975-06       Impact factor: 10.057
  9 in total
  2 in total

Review 1.  Skeletal uptake of diphosphonate: a review.

Authors:  I Fogelman
Journal:  Eur J Nucl Med       Date:  1980-12

2.  Increased bone metabolism in rheumatoid arthritis as measured by the whole-body retention of 99Tcm methylene diphosphonate.

Authors:  C Rajapakse; R Thompson; D M Grennan; B M Winston; P Patel; P M Nuttall; J Murphy; J B Weiss
Journal:  Ann Rheum Dis       Date:  1983-04       Impact factor: 19.103
  2 in total

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