Literature DB >> 8914776

Macrofragment localization of the toxin A and toxin B genes of Clostridium difficile.

D A Norwood1, J A Sands.   

Abstract

We report the physical mapping of the toxin A and B genes to the bacterial chromosome of Clostridium difficile ATCC 43594 by pulsed-field gel electrophoresis. Single and double digestions with restriction endonucleases NruI and SacII allowed localization of the toxin genes to a specific 577-kb fragment and estimation of genome size to be approximately 3.8 megabases. This effort represents the initial step in the construction of a physical map of the whole genome.

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Year:  1996        PMID： 8914776      PMCID： PMC170448          DOI： 10.1128/cdli.3.6.782-785.1996

Source DB:  PubMed          Journal:  Clin Diagn Lab Immunol        ISSN： 1071-412X


  16 in total

1.  Nucleotide sequence of Clostridium difficile toxin A.

Authors:  M Sauerborn; C von Eichel-Streiber
Journal:  Nucleic Acids Res       Date:  1990-03-25       Impact factor: 16.971

2.  Mechanism of action of Clostridium difficile toxin B: role of external medium and cytoskeletal organization in intoxicated cells.

Authors:  J Ciesielski-Treska; G Ulrich; B Rihn; D Aunis
Journal:  Eur J Cell Biol       Date:  1989-04       Impact factor: 4.492

Review 3.  The ecology of the human intestine and its consequences for overgrowth by pathogens such as Clostridium difficile.

Authors:  D van der Waaij
Journal:  Annu Rev Microbiol       Date:  1989       Impact factor: 15.500

4.  Nosocomial Clostridium difficile infections.

Authors:  J J Cimino
Journal:  N Engl J Med       Date:  1989-07-20       Impact factor: 91.245

5.  Glucosylation of Rho proteins by Clostridium difficile toxin B.

Authors:  I Just; J Selzer; M Wilm; C von Eichel-Streiber; M Mann; K Aktories
Journal:  Nature       Date:  1995-06-08       Impact factor: 49.962

6.  Purification and characterization of toxins A and B of Clostridium difficile.

Authors:  N M Sullivan; S Pellett; T D Wilkins
Journal:  Infect Immun       Date:  1982-03       Impact factor: 3.441

7.  Bacteriotherapy for chronic relapsing Clostridium difficile diarrhoea in six patients.

Authors:  M Tvede; J Rask-Madsen
Journal:  Lancet       Date:  1989-05-27       Impact factor: 79.321

8.  Contamination of endoscopes used in AIDS patients.

Authors:  P J Hanson; D Gor; J R Clarke; M V Chadwick; G Nicholson; N Shah; B Gazzard; D J Jeffries; H Gaya; J V Collins
Journal:  Lancet       Date:  1989-07-08       Impact factor: 79.321

9.  Clostridium difficile toxin A perturbs cytoskeletal structure and tight junction permeability of cultured human intestinal epithelial monolayers.

Authors:  G Hecht; C Pothoulakis; J T LaMont; J L Madara
Journal:  J Clin Invest       Date:  1988-11       Impact factor: 14.808

10.  Clostridium difficile toxin A stimulates intracellular calcium release and chemotactic response in human granulocytes.

Authors:  C Pothoulakis; R Sullivan; D A Melnick; G Triadafilopoulos; A S Gadenne; T Meshulam; J T LaMont
Journal:  J Clin Invest       Date:  1988-06       Impact factor: 14.808
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