Literature DB >> 8914574

The human intestinal H+/oligopeptide cotransporter hPEPT1 transports differently-charged dipeptides with identical electrogenic properties.

B Mackenzie1, Y J Fei, V Ganapathy, F H Leibach.   

Abstract

The human intestinal H+/oligopeptide cotransporter hPEPT1, expressed in Xenopus oocytes, transported neutral, anionic and cationic dipeptides with identical electrogenic properties and maximal evoked currents. Currents were activated by 1 H+ regardless of the net charge on the driven substrate, and were independent of Na+o, K+i and Clo-, calling into question the familiar concept of the origin of the transporter-mediated current.

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Year:  1996        PMID: 8914574     DOI: 10.1016/s0005-2736(96)00170-8

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN: 0006-3002


  13 in total

1.  Changes of biological functions of dipeptide transporter (PepT1) and hormonal regulation in severe scald rats.

Authors:  Bing-Wei Sun; Xiao-Chen Zhao; Guang-Ji Wang; Ning Li; Jie-Shou Li
Journal:  World J Gastroenterol       Date:  2003-12       Impact factor: 5.742

2.  First insights into the operational mode of epithelial peptide transporters.

Authors:  H Daniel
Journal:  J Physiol       Date:  1997-02-01       Impact factor: 5.182

Review 3.  Function, Regulation, and Pathophysiological Relevance of the POT Superfamily, Specifically PepT1 in Inflammatory Bowel Disease.

Authors:  Emilie Viennois; Adani Pujada; Jane Zen; Didier Merlin
Journal:  Compr Physiol       Date:  2018-03-25       Impact factor: 9.090

4.  Peptide transporter 1 is responsible for intestinal uptake of the dipeptide glycylsarcosine: studies in everted jejunal rings from wild-type and Pept1 null mice.

Authors:  Katherine Ma; Yongjun Hu; David E Smith
Journal:  J Pharm Sci       Date:  2010-09-22       Impact factor: 3.534

5.  Computational modelling of H+-coupled peptide transport via human PEPT1.

Authors:  Megumi Irie; Tomohiro Terada; Toshiya Katsura; Satoshi Matsuoka; Ken-ichi Inui
Journal:  J Physiol       Date:  2005-03-31       Impact factor: 5.182

6.  Stoichiometry and pH dependence of the rabbit proton-dependent oligopeptide transporter PepT1.

Authors:  A Steel; S Nussberger; M F Romero; W F Boron; C A Boyd; M A Hediger
Journal:  J Physiol       Date:  1997-02-01       Impact factor: 5.182

7.  Bidirectional electrogenic transport of peptides by the proton-coupled carrier PEPT1 in Xenopus laevis oocytes: its asymmetry and symmetry.

Authors:  G Kottra; H Daniel
Journal:  J Physiol       Date:  2001-10-15       Impact factor: 5.182

8.  hPepT1-mediated epithelial transport of bacteria-derived chemotactic peptides enhances neutrophil-epithelial interactions.

Authors:  D Merlin; A Steel; A T Gewirtz; M Si-Tahar; M A Hediger; J L Madara
Journal:  J Clin Invest       Date:  1998-12-01       Impact factor: 14.808

9.  Relevance of NAC-2, an Na+-coupled citrate transporter, to life span, body size and fat content in Caenorhabditis elegans.

Authors:  You-Jun Fei; Jin-Cai Liu; Katsuhisa Inoue; Lina Zhuang; Katsuya Miyake; Seiji Miyauchi; Vadivel Ganapathy
Journal:  Biochem J       Date:  2004-04-01       Impact factor: 3.857

Review 10.  Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications.

Authors:  David E Smith; Benjamin Clémençon; Matthias A Hediger
Journal:  Mol Aspects Med       Date:  2013 Apr-Jun
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