Literature DB >> 8912633

Cloning and expression of mouse UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-T3.

J Zara1, F K Hagen, K G Ten Hagen, B C Van Wuyckhuyse, L A Tabak.   

Abstract

A novel isoform of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, designated ppGaNTase-T3, has been cloned from a mouse testis cDNA library and expressed in COS7 cells. ppGaNTase-T3 displayed 64 and 59% amino acid identity with ppGaNTase-T1 and ppGaNTase-T2, respectively, and 96% amino acid identity with the recently reported human form of ppGaNTase-T3. The ppGaNTase-T3 transcript is abundant in the major salivary glands, gastrointestinal tract and both the male and female reproductive systems. ppGaNTase-T3 and ppGaNTase-T1 display overlapping substrate preferences in vitro, although mapping studies of O-glycosylated peptides suggests that certain hydroxyamino acids are preferentially glycosylated by each isoform. This suggests that more than one isoform of ppGaNTase may be required to complete the O-glycosylation of endogenous substrates.

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Year:  1996        PMID： 8912633     DOI： 10.1006/bbrc.1996.1613

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  13 in total

1.  NetOglyc: prediction of mucin type O-glycosylation sites based on sequence context and surface accessibility.

Authors:  J E Hansen; O Lund; N Tolstrup; A A Gooley; K L Williams; S Brunak
Journal:  Glycoconj J       Date:  1998-02       Impact factor: 2.916

2.  Differential splicing of the lectin domain of an O-glycosyltransferase modulates both peptide and glycopeptide preferences.

Authors:  Carolyn May; Suena Ji; Zulfeqhar A Syed; Leslie Revoredo; Earnest James Paul Daniel; Thomas A Gerken; Lawrence A Tabak; Nadine L Samara; Kelly G Ten Hagen
Journal:  J Biol Chem       Date:  2020-07-15       Impact factor: 5.157

3.  Isoform-specific O-glycosylation of osteopontin and bone sialoprotein by polypeptide N-acetylgalactosaminyltransferase-1.

Authors:  Hazuki E Miwa; Thomas A Gerken; Oliver Jamison; Lawrence A Tabak
Journal:  J Biol Chem       Date:  2009-10-30       Impact factor: 5.157

Review 4.  Mucin-type O-glycosylation during development.

Authors:  Duy T Tran; Kelly G Ten Hagen
Journal:  J Biol Chem       Date:  2013-01-17       Impact factor: 5.157

5.  Mechanism of FGF23 processing in fibrous dysplasia.

Authors:  Nisan Bhattacharyya; Malgorzata Wiench; Claudia Dumitrescu; Brian M Connolly; Thomas H Bugge; Himatkumar V Patel; Rachel I Gafni; Natasha Cherman; Monique Cho; Gordon L Hager; Michael T Collins
Journal:  J Bone Miner Res       Date:  2012-05       Impact factor: 6.741

6.  Identification of essential histidine residues in UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase-T1.

Authors:  S Wragg; F K Hagen; L A Tabak
Journal:  Biochem J       Date:  1997-11-15       Impact factor: 3.857

7.  Glycosylation of α-dystroglycan: O-mannosylation influences the subsequent addition of GalNAc by UDP-GalNAc polypeptide N-acetylgalactosaminyltransferases.

Authors:  Duy T Tran; Jae-Min Lim; Mian Liu; Stephanie H Stalnaker; Lance Wells; Kelly G Ten Hagen; David Live
Journal:  J Biol Chem       Date:  2012-05-01       Impact factor: 5.157

Review 8.  Recent insights into the biological roles of mucin-type O-glycosylation.

Authors:  E Tian; Kelly G Ten Hagen
Journal:  Glycoconj J       Date:  2008-08-10       Impact factor: 2.916

9.  Characterization of a UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase with an unusual lectin domain from the platyhelminth parasite Echinococcus granulosus.

Authors:  Teresa Freire; Cecilia Fernández; Cora Chalar; Rick M Maizels; Pedro Alzari; Eduardo Osinaga; Carlos Robello
Journal:  Biochem J       Date:  2004-09-01       Impact factor: 3.857

10.  Loss of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 3 and reduced O-glycosylation in colon carcinoma cells selected for hepatic metastasis.

Authors:  Kentaro Kato; Hideyuki Takeuchi; Akira Kanoh; Naoki Miyahara; Yoko Nemoto-Sasaki; Megumi Morimoto-Tomita; Azusa Matsubara; Yoshimi Ohashi; Michihiko Waki; Katsuaki Usami; Ulla Mandel; Henrik Clausen; Nobuaki Higashi; Tatsuro Irimura
Journal:  Glycoconj J       Date:  2010-02       Impact factor: 2.916
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