Literature DB >> 8912177

Guanine nucleotide exchange factors for the Rho GTPases: a role in human disease?

M F Olson1.   

Abstract

The Rho family of low molecular weight GTP-binding proteins control important aspects of cell shape, adhesion, movement and growth. The DBL-homology (DH) protein family of upstream regulators of Rho GTPases has recently been identified, and deregulated expression of these proteins can have dramatic cellular consequences. This review examines the possible role of DH proteins and Rho GTPases in oncogenesis, metastasis and development.

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Year:  1996        PMID： 8912177     DOI： 10.1007/s001090050060

Source DB:  PubMed          Journal:  J Mol Med (Berl)        ISSN： 0946-2716            Impact factor:   4.599


  15 in total

1.  Modulation of endocytic traffic in polarized Madin-Darby canine kidney cells by the small GTPase RhoA.

Authors:  S M Leung; R Rojas; C Maples; C Flynn; W G Ruiz; T S Jou; G Apodaca
Journal:  Mol Biol Cell       Date:  1999-12       Impact factor: 4.138

Review 2.  Clostridial toxins: molecular probes of Rho-dependent signaling and apoptosis.

Authors:  D A Bobak
Journal:  Mol Cell Biochem       Date:  1999-03       Impact factor: 3.396

3.  Selective alterations in biosynthetic and endocytic protein traffic in Madin-Darby canine kidney epithelial cells expressing mutants of the small GTPase Rac1.

Authors:  T S Jou; S M Leung; L M Fung; W G Ruiz; W J Nelson; G Apodaca
Journal:  Mol Biol Cell       Date:  2000-01       Impact factor: 4.138

4.  Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia.

Authors:  P J Kourlas; M P Strout; B Becknell; M L Veronese; C M Croce; K S Theil; R Krahe; T Ruutu; S Knuutila; C D Bloomfield; M A Caligiuri
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-29       Impact factor: 11.205

5.  Ras-specific exchange factor GRF: oligomerization through its Dbl homology domain and calcium-dependent activation of Raf.

Authors:  P H Anborgh; X Qian; A G Papageorge; W C Vass; J E DeClue; D R Lowy
Journal:  Mol Cell Biol       Date:  1999-07       Impact factor: 4.272

Review 6.  Molecular biology of chronic myeloid leukemia.

Authors:  Y Maru
Journal:  Int J Hematol       Date:  2001-04       Impact factor: 2.490

Review 7.  Cdc42: An essential Rho-type GTPase controlling eukaryotic cell polarity.

Authors:  D I Johnson
Journal:  Microbiol Mol Biol Rev       Date:  1999-03       Impact factor: 11.056

8.  Constitutively active RhoA inhibits proliferation by retarding G(1) to S phase cell cycle progression and impairing cytokinesis.

Authors:  Pierre Morin; Cristina Flors; Michael F Olson
Journal:  Eur J Cell Biol       Date:  2009-06-09       Impact factor: 4.492

9.  Type I collagen receptor (alpha2beta1) signaling promotes prostate cancer invasion through RhoC GTPase.

Authors:  Christopher L Hall; Cara W Dubyk; Tracy A Riesenberger; Daniel Shein; Evan T Keller; Kenneth L van Golen
Journal:  Neoplasia       Date:  2008-08       Impact factor: 5.715

10.  Regulatory roles for Tiam1, a guanine nucleotide exchange factor for Rac1, in glucose-stimulated insulin secretion in pancreatic beta-cells.

Authors:  Rajakrishnan Veluthakal; Suresh Vasu Madathilparambil; Phillip McDonald; Lawrence Karl Olson; Anjaneyulu Kowluru
Journal:  Biochem Pharmacol       Date:  2008-09-27       Impact factor: 5.858
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