OBJECTIVE: The effects of vitamin D deficiency in osteopenic postmenopausal women treated with intermittent cyclical etidronate have been studied. Bone mass and biochemical parameters as bone markers were measured before and after one year of therapy with intermittent cyclical etidronate. RESULTS: In 30 patients without vitamin D deficiency, bone mass in the lumbal spine and femoral neck was significantly increased compared to 28 vitamin D deficient patients. After cyclical intermittent etidronate therapy, serum osteocalcin and PTH were significantly increased in the vitamin D deficient patients, whereas in non-vitamin D deficient patients they did not change. CONCLUSION: It is worthwhile measuring serum vitamin D before starting etidronate therapy and, in case of deficiency, to give vitamin D.
OBJECTIVE: The effects of vitamin Ddeficiency in osteopenic postmenopausal women treated with intermittent cyclical etidronate have been studied. Bone mass and biochemical parameters as bone markers were measured before and after one year of therapy with intermittent cyclical etidronate. RESULTS: In 30 patients without vitamin D deficiency, bone mass in the lumbal spine and femoral neck was significantly increased compared to 28 vitamin D deficient patients. After cyclical intermittent etidronate therapy, serum osteocalcin and PTH were significantly increased in the vitamin D deficient patients, whereas in non-vitamin D deficient patients they did not change. CONCLUSION: It is worthwhile measuring serum vitamin D before starting etidronate therapy and, in case of deficiency, to give vitamin D.
Authors: Johann D Ringe; Patrice Fardellone; Hans-Peter Kruse; Michael Amling; Stefan A P van der Geest; Gerd Möller Journal: Drugs Aging Date: 2009 Impact factor: 3.923
Authors: Edward P Weiss; Krupa Shah; Luigi Fontana; Charles P Lambert; John O Holloszy; Dennis T Villareal Journal: Am J Clin Nutr Date: 2009-03-25 Impact factor: 7.045
Authors: S Boonen; R Rizzoli; P J Meunier; M Stone; G Nuki; U Syversen; M Lehtonen-Veromaa; P Lips; O Johnell; J-Y Reginster Journal: Osteoporos Int Date: 2004-07 Impact factor: 4.507