Literature DB >> 8910958

Logrank, play the winner, power and ethics.

A Hallstrom1, M M Brooks, M Peckova.   

Abstract

We show by simulation and numerical integration techniques that power is largely unaffected by play the winner strategies in a typical chronic disease mortality trial utilizing the logrank test. This raises the issue of the ethics of equal allocation in such a setting.

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Year:  1996        PMID: 8910958     DOI: 10.1002/(SICI)1097-0258(19961030)15:20<2135::AID-SIM355>3.0.CO;2-G

Source DB:  PubMed          Journal:  Stat Med        ISSN: 0277-6715            Impact factor:   2.373


  2 in total

1.  A Bayesian adaptive design for two-stage clinical trials with survival data.

Authors:  Uttam Bandyopadhyay; Atanu Biswas; Rahul Bhattacharya
Journal:  Lifetime Data Anal       Date:  2009-11-04       Impact factor: 1.588

2.  The clinically-integrated randomized trial: proposed novel method for conducting large trials at low cost.

Authors:  Andrew J Vickers; Peter T Scardino
Journal:  Trials       Date:  2009-03-05       Impact factor: 2.279

  2 in total

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