Literature DB >> 8910948

Formaldehyde mechanistic data and risk assessment: endogenous protection from DNA adduct formation.

C C Conaway1, J Whysner, L K Verna, G M Williams.   

Abstract

Exposures of rodents to airborne formaldehyde (FA) produce dose-related toxicity, enhanced cell proliferation and squamous cell carcinomas in the nasal passages. The mechanism of FA-induced tumor formation involves DNA-protein crosslink formation and enhanced cell proliferation secondarily to cytotoxicity. The mucociliary apparatus and glutathione protect against low-dose FA-induced effects. Consequently, the mechanistic information is consistent with a very sublinear dose-response curve for tumor formation. The sublinear dose-response of nasal DNA-protein crosslinks levels in rodents and monkeys has been used in the risk assessment of FA.

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Year:  1996        PMID： 8910948     DOI： 10.1016/0163-7258(96)00061-7

Source DB:  PubMed          Journal:  Pharmacol Ther        ISSN： 0163-7258            Impact factor:   12.310


  14 in total

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2.  Incision of DNA-protein crosslinks by UvrABC nuclease suggests a potential repair pathway involving nucleotide excision repair.

Authors:  Irina G Minko; Yue Zou; R Stephen Lloyd
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-12       Impact factor: 11.205

3.  Tandem Deubiquitination and Acetylation of SPRTN Promotes DNA-Protein Crosslink Repair and Protects against Aging.

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Journal:  Mol Cell       Date:  2020-07-09       Impact factor: 17.970

Review 4.  Formation and repair of DNA-protein crosslink damage.

Authors:  Naeh L Klages-Mundt; Lei Li
Journal:  Sci China Life Sci       Date:  2017-10-30       Impact factor: 6.038

5.  Infusion fluids contain harmful glucose degradation products.

Authors:  Anna Bryland; Marcus Broman; Martin Erixon; Bengt Klarin; Torbjörn Lindén; Hans Friberg; Anders Wieslander; Per Kjellstrand; Claudio Ronco; Ola Carlsson; Gabriela Godaly
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6.  DNA-protein crosslinks and p53 protein expression in relation to occupational exposure to formaldehyde.

Authors:  J Shaham; Y Bomstein; R Gurvich; M Rashkovsky; Z Kaufman
Journal:  Occup Environ Med       Date:  2003-06       Impact factor: 4.402

7.  Detection of DNA-protein crosslinks (DPCs) by novel direct fluorescence labeling methods: distinct stabilities of aldehyde and radiation-induced DPCs.

Authors:  Mahmoud I Shoulkamy; Toshiaki Nakano; Makiko Ohshima; Ryoichi Hirayama; Akiko Uzawa; Yoshiya Furusawa; Hiroshi Ide
Journal:  Nucleic Acids Res       Date:  2012-06-22       Impact factor: 16.971

8.  The Effectors and Sensory Sites of Formaldehyde-responsive Regulator FrmR and Metal-sensing Variant.

Authors:  Deenah Osman; Cecilia Piergentili; Junjun Chen; Lucy N Sayer; Isabel Usón; Thomas G Huggins; Nigel J Robinson; Ehmke Pohl
Journal:  J Biol Chem       Date:  2016-07-29       Impact factor: 5.157

9.  Reduction of Endogenous Melatonin Accelerates Cognitive Decline in Mice in a Simulated Occupational Formaldehyde Exposure Environment.

Authors:  Yufei Mei; Chunli Duan; Xiaoxiao Li; Yun Zhao; Fenghua Cao; Shuai Shang; Shumao Ding; Xiangpei Yue; Ge Gao; Hui Yang; Luxi Shen; Xueyan Feng; Jianping Jia; Zhiqian Tong; Xu Yang
Journal:  Int J Environ Res Public Health       Date:  2016-02-29       Impact factor: 3.390

Review 10.  Formaldehyde Stress Responses in Bacterial Pathogens.

Authors:  Nathan H Chen; Karrera Y Djoko; Frédéric J Veyrier; Alastair G McEwan
Journal:  Front Microbiol       Date:  2016-03-03       Impact factor: 5.640
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