Literature DB >> 8910276

Major susceptibility locus for prostate cancer on chromosome 1 suggested by a genome-wide search.

J R Smith1, D Freije, J D Carpten, H Grönberg, J Xu, S D Isaacs, M J Brownstein, G S Bova, H Guo, P Bujnovszky, D R Nusskern, J E Damber, A Bergh, M Emanuelsson, O P Kallioniemi, J Walker-Daniels, J E Bailey-Wilson, T H Beaty, D A Meyers, P C Walsh, F S Collins, J M Trent, W B Isaacs.   

Abstract

Despite its high prevalence, very little is known regarding genetic predisposition to prostate cancer. A genome-wide scan performed in 66 high-risk prostate cancer families has provided evidence of linkage to the long arm of chromosome 1 (1q24-25). Analysis of an additional set of 25 North American and Swedish families with markers in this region resulted in significant evidence of linkage in the combined set of 91 families. The data provide strong evidence of a major prostate cancer susceptibility locus on chromosome 1.

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Year:  1996        PMID： 8910276     DOI： 10.1126/science.274.5291.1371

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  149 in total

1.  Highly skewed X-chromosome inactivation is associated with idiopathic recurrent spontaneous abortion.

Authors:  M C Lanasa; W A Hogge; C Kubik; J Blancato; E P Hoffman
Journal:  Am J Hum Genet       Date:  1999-07       Impact factor: 11.025

Review 2.  Molecular profiling of clinical tissues specimens: feasibility and applications.

Authors:  M R Emmert-Buck; R L Strausberg; D B Krizman; M F Bonaldo; R F Bonner; D G Bostwick; M R Brown; K H Buetow; R F Chuaqui; K A Cole; P H Duray; C R Englert; J W Gillespie; S Greenhut; L Grouse; L W Hillier; K S Katz; R D Klausner; V Kuznetzov; A E Lash; G Lennon; W M Linehan; L A Liotta; M A Marra; P J Munson; D K Ornstein; V V Prabhu; C Prang; G D Schuler; M B Soares; C M Tolstoshev; C D Vocke; R H Waterston
Journal:  J Mol Diagn       Date:  2000-05       Impact factor: 5.568

3.  Segregation analyses of 1,476 population-based Australian families affected by prostate cancer.

Authors:  J Cui; M P Staples; J L Hopper; D R English; M R McCredie; G G Giles
Journal:  Am J Hum Genet       Date:  2001-04-11       Impact factor: 11.025

4.  Model-free linkage analysis with covariates confirms linkage of prostate cancer to chromosomes 1 and 4.

Authors:  K A Goddard; J S Witte; B K Suarez; W J Catalona; J M Olson
Journal:  Am J Hum Genet       Date:  2001-04-13       Impact factor: 11.025

Review 5.  Prostate cancer prevention: review of target populations, pathological biomarkers, and chemopreventive agents.

Authors:  R Montironi; R Mazzucchelli; J R Marshall; P H Bartels
Journal:  J Clin Pathol       Date:  1999-11       Impact factor: 3.411

Review 6.  Molecular profiling of clinical tissue specimens: feasibility and applications.

Authors:  M R Emmert-Buck; R L Strausberg; D B Krizman; M F Bonaldo; R F Bonner; D G Bostwick; M R Brown; K H Buetow; R F Chuaqui; K A Cole; P H Duray; C R Englert; J W Gillespie; S Greenhut; L Grouse; L W Hillier; K S Katz; R D Klausner; V Kuznetzov; A E Lash; G Lennon; W M Linehan; L A Liotta; M A Marra; P J Munson; D K Ornstein; V V Prabhu; C Prange; G D Schuler; M B Soares; C M Tolstoshev; C D Vocke; R H Waterston
Journal:  Am J Pathol       Date:  2000-04       Impact factor: 4.307

7.  A genome screen of multiplex sibships with prostate cancer.

Authors:  B K Suarez; J Lin; J K Burmester; K W Broman; J L Weber; T K Banerjee; K A Goddard; J S Witte; R C Elston; W J Catalona
Journal:  Am J Hum Genet       Date:  2000-03       Impact factor: 11.025

8.  A genomic scan of families with prostate cancer identifies multiple regions of interest.

Authors:  M Gibbs; J L Stanford; G P Jarvik; M Janer; M Badzioch; M A Peters; E L Goode; S Kolb; L Chakrabarti; M Shook; R Basom; E A Ostrander; L Hood
Journal:  Am J Hum Genet       Date:  2000-05-19       Impact factor: 11.025

9.  Evidence for a prostate cancer-susceptibility locus on chromosome 20.

Authors:  R Berry; J J Schroeder; A J French; S K McDonnell; B J Peterson; J M Cunningham; S N Thibodeau; D J Schaid
Journal:  Am J Hum Genet       Date:  2000-05-16       Impact factor: 11.025

10.  Linkage analyses at the chromosome 1 loci 1q24-25 (HPC1), 1q42.2-43 (PCAP), and 1p36 (CAPB) in families with hereditary prostate cancer.

Authors:  R Berry; D J Schaid; J R Smith; A J French; J J Schroeder; S K McDonnell; B J Peterson; Z Y Wang; J D Carpten; S G Roberts; D J Tester; M L Blute; J M Trent; S N Thibodeau
Journal:  Am J Hum Genet       Date:  2000-02       Impact factor: 11.025
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