STUDY OBJECTIVE: To define the optimal dose of lidocaine to be added to propofol to reduce the incidence of pain during its injection. DESIGN: Double-blind, randomized, placebo-controlled study. SETTING: Medical center operating rooms. PATIENTS: 135 ASA I and II female patients undergoing minor outpatient surgery. INTERVENTIONS: Patients were randomly allocated to one of five groups: Group A (control), no lidocaine: Group B, lidocaine 10 mg: Group C, lidocaine 20 mg; Group D, lidocaine 30 mg; Group F, lidocaine 40 mg. For each patient, pain during injection of the propofol solution was graded as none, mild, moderate, or severe. MEASUREMENTS AND MAIN RESULTS: The incidence of pain in the control group was 85%. All treatment groups receiving lidocaine had a significantly lower incidence of pain compared with the control group (P < 0.001). The lidocaine 30 mg and 40 mg groups both had a 7% incidence of pain, which was significantly less than a 33% incidence in the lidocaine 10 mg group (P < 0.05). CONCLUSIONS: Within this dose range and in this patient population, 30 mg of lidocaine is optimal for reducing the pain during injection of propofol.
RCT Entities:
STUDY OBJECTIVE: To define the optimal dose of lidocaine to be added to propofol to reduce the incidence of pain during its injection. DESIGN: Double-blind, randomized, placebo-controlled study. SETTING: Medical center operating rooms. PATIENTS: 135 ASA I and II female patients undergoing minor outpatient surgery. INTERVENTIONS:Patients were randomly allocated to one of five groups: Group A (control), no lidocaine: Group B, lidocaine 10 mg: Group C, lidocaine 20 mg; Group D, lidocaine 30 mg; Group F, lidocaine 40 mg. For each patient, pain during injection of the propofol solution was graded as none, mild, moderate, or severe. MEASUREMENTS AND MAIN RESULTS: The incidence of pain in the control group was 85%. All treatment groups receiving lidocaine had a significantly lower incidence of pain compared with the control group (P < 0.001). The lidocaine 30 mg and 40 mg groups both had a 7% incidence of pain, which was significantly less than a 33% incidence in the lidocaine 10 mg group (P < 0.05). CONCLUSIONS: Within this dose range and in this patient population, 30 mg of lidocaine is optimal for reducing the pain during injection of propofol.
Authors: Hyun-Sik Kim; Kwang Rae Cho; Jeong Han Lee; Young Hwan Kim; Se Hun Lim; Kun Moo Lee; Soon Ho Cheong; Young Jae Kim; Chee-Mahn Shin; Jin-Young Lee Journal: Korean J Anesthesiol Date: 2010-11-25