Literature DB >> 8908686

Hippocampal age-related changes in schizophrenia: a proton magnetic resonance spectroscopy study.

M Maier1, M A Ron.   

Abstract

We have used proton magnetic resonance spectroscopy to study in vivo N-acetyl aspartate (NAA), choline and creatine in the hippocampi of 26 schizophrenics and 38 normal controls. Measurements of NAA suggest that age-related neuronal loss occurs at a similar rate in schizophrenics and controls. On the other hand, we observe in schizophrenics age-related choline abnormalities not present in controls. We suggest that these age-related changes may be related to an abnormal myelination process and contribute to the observed clinical deterioration associated with schizophrenia.

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Year:  1996        PMID： 8908686     DOI： 10.1016/0920-9964(96)00044-8

Source DB:  PubMed          Journal:  Schizophr Res        ISSN： 0920-9964            Impact factor:   4.939


  9 in total

Review 1.  Neurometabolites in schizophrenia and bipolar disorder - a systematic review and meta-analysis.

Authors:  Nina Vanessa Kraguljac; Meredith Reid; David White; Rebecca Jones; Jan den Hollander; Deborah Lowman; Adrienne Carol Lahti
Journal:  Psychiatry Res       Date:  2012-09-13       Impact factor: 3.222

2.  Human QKI, a potential regulator of mRNA expression of human oligodendrocyte-related genes involved in schizophrenia.

Authors:  Karolina Aberg; Peter Saetre; Niclas Jareborg; Elena Jazin
Journal:  Proc Natl Acad Sci U S A       Date:  2006-04-25       Impact factor: 11.205

Review 3.  [Magnetic resonance spectroscopy in schizophrenia. Possibilities and limitations].

Authors:  T Wobrock; H Scherk; P Falkai
Journal:  Radiologe       Date:  2005-02       Impact factor: 0.635

Review 4.  1H MR spectroscopy in patients with mesial temporal epilepsy.

Authors:  M Hájek; M Dezortová; V Komárek
Journal:  MAGMA       Date:  1998-12       Impact factor: 2.310

5.  Increased hippocampal glutamate and volumetric deficits in unmedicated patients with schizophrenia.

Authors:  Nina V Kraguljac; David M White; Meredith A Reid; Adrienne C Lahti
Journal:  JAMA Psychiatry       Date:  2013-12       Impact factor: 21.596

Review 6.  T2 relaxation effects on apparent N-acetylaspartate concentration in proton magnetic resonance studies of schizophrenia.

Authors:  Bethany K Bracken; Elizabeth D Rouse; Perry F Renshaw; David P Olson
Journal:  Psychiatry Res       Date:  2013-06-12       Impact factor: 3.222

7.  In vivo investigation of white matter pathology in schizophrenia with magnetisation transfer imaging.

Authors:  J Foong; M Maier; G J Barker; S Brocklehurst; D H Miller; M A Ron
Journal:  J Neurol Neurosurg Psychiatry       Date:  2000-01       Impact factor: 10.154

8.  Neural models of schizophrenia.

Authors:  S Heckers
Journal:  Dialogues Clin Neurosci       Date:  2000-09       Impact factor: 5.986

9.  NPAS3 variants in schizophrenia: a neuroimaging study.

Authors:  Denise Bernier; Georgina Macintyre; Robert Bartha; Christopher C Hanstock; David McAllindon; Diane Cox; Scot Purdon; Katherine J Aitchison; Benjamin Rusak; Philip G Tibbo
Journal:  BMC Med Genet       Date:  2014-03-27       Impact factor: 2.103
  9 in total

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