Literature DB >> 890838

Subcellular distribution, a factor in risk evaluation of pentachlorophenol.

E Arrhenius, L Renberg, L Johansson.   

Abstract

Pentachlorophenol (PCP) is a potent uncoupler of mitochondrial phosphorylation in vitro and also interferes with microsomal detoxication functions in vitro. This favours flavin mediated oxygenation compared with flavin cytochrome P-450 dependent reactions. Gas chromatographic analysis of subcellular fractions, obtained by zonal centrifugation showed markedly lower PCP concentration in mitochondria and a high accumulation in microsomes compared with cytosol. This increases the likelihood that PCP in vivo causes a malfunction in microsomal detoxication.

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Year:  1977        PMID： 890838     DOI： 10.1016/0009-2797(77)90138-7

Source DB:  PubMed          Journal:  Chem Biol Interact        ISSN： 0009-2797            Impact factor:   5.192


  6 in total

1.  Ultrastructural alterations in the livers of golden hamsters following experimental chronic inhalation of diluted diesel exhaust emission.

Authors:  R Meiss; H Robenek; M Schubert; H Themann; U Heinrich
Journal:  Int Arch Occup Environ Health       Date:  1981       Impact factor: 3.015

2.  Isolation and characterization of palmitoylpentachlorophenol from human fat.

Authors:  G A Ansari; S G Britt; E S Reynolds
Journal:  Bull Environ Contam Toxicol       Date:  1985-05       Impact factor: 2.151

3.  Conjugation of pentachlorophenol to palmitic acid by liver microsomes.

Authors:  E G Leighty; A F Fentiman
Journal:  Bull Environ Contam Toxicol       Date:  1982-03       Impact factor: 2.151

4.  Metabolism of pentachlorophenol to tetrachlorohydroquinone by human liver homogenate.

Authors:  U Juhl; I Witte; W Butte
Journal:  Bull Environ Contam Toxicol       Date:  1985-11       Impact factor: 2.151

5.  Acute and short-term toxicity of 2,3,4,6-tetrachlorophenol in rats.

Authors:  M L Hattula; V M Wasenius; R Krees; A U Arstila; M Kihlström
Journal:  Bull Environ Contam Toxicol       Date:  1981-06       Impact factor: 2.151

6.  Ultrastructural morphometric investigations on rat liver of young and adult rats after treatment with technical pentachlorophenol (PCP).

Authors:  M Fleischer; R Meiss; H Robenek; H Themann; R Eckard
Journal:  Arch Toxicol       Date:  1980-04       Impact factor: 5.153
  6 in total

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