Literature DB >> 8905731

GABA metabolism controls inhibition efficacy in the mammalian CNS.

H Golan1, A E Talpalar, D Schleifstein-Attias, Y Grossman.   

Abstract

The effects of changes in gamma-aminobutyric acid (GABA) metabolism or inhibitory processes was studied in the perforant path-dentate gyrus synapses in rat cortico-hippocampal slices, and in the monosynaptic-reflex circuit in isolated newborn, rat spinal cord. GABA metabolism was modulated by pharmacological block of either the anabolic enzyme glutamate decarboxylase (GAD) or the catabolic enzyme GABA transaminase (GABA-T). The results support the notion that GABA concentration determines the efficacy of inhibition in these regions of the central nervous system (CNS).

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Year:  1996        PMID： 8905731     DOI： 10.1016/0304-3940(96)13061-5

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  7 in total

1.  GABA and primary motor cortex inhibition in young and older adults: a multimodal reliability study.

Authors:  Ronan A Mooney; John Cirillo; Winston D Byblow
Journal:  J Neurophysiol       Date:  2017-04-19       Impact factor: 2.714

2.  Inhibition of uptake, steady-state currents, and transient charge movements generated by the neuronal GABA transporter by various anticonvulsant drugs.

Authors:  U Eckstein-Ludwig; J Fei; W Schwarz
Journal:  Br J Pharmacol       Date:  1999-09       Impact factor: 8.739

3.  Abnormal relationship between GABA, neurophysiology and impulsive behavior in neurofibromatosis type 1.

Authors:  Maria J Ribeiro; Inês R Violante; Inês Bernardino; Richard A E Edden; Miguel Castelo-Branco
Journal:  Cortex       Date:  2014-11-11       Impact factor: 4.027

4.  A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy.

Authors:  Jehuda P Sepkuty; Akiva S Cohen; Christine Eccles; Azhar Rafiq; Kevin Behar; Raquelli Ganel; Douglas A Coulter; Jeffrey D Rothstein
Journal:  J Neurosci       Date:  2002-08-01       Impact factor: 6.167

5.  The role of GABA in human motor learning.

Authors:  Charlotte J Stagg; Velicia Bachtiar; Heidi Johansen-Berg
Journal:  Curr Biol       Date:  2011-03-03       Impact factor: 10.834

6.  Relationship between physiological measures of excitability and levels of glutamate and GABA in the human motor cortex.

Authors:  C J Stagg; S Bestmann; A O Constantinescu; L Moreno Moreno; C Allman; R Mekle; M Woolrich; J Near; H Johansen-Berg; J C Rothwell
Journal:  J Physiol       Date:  2011-10-17       Impact factor: 5.182

7.  Neurophysiological modulations in the (pre)motor-motor network underlying age-related increases in reaction time and the role of GABA levels - a bimodal TMS-MRS study.

Authors:  Stefanie Verstraelen; Koen Cuypers; Celine Maes; Melina Hehl; Shanti Van Malderen; Oron Levin; Mark Mikkelsen; Raf L J Meesen; Stephan P Swinnen
Journal:  Neuroimage       Date:  2021-08-21       Impact factor: 6.556
  7 in total

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