| Literature DB >> 890559 |
E P Steffey, R Martucci, D Howland, J H Asling, J H Eisele.
Abstract
We studied the interaction of meperidine and halothane in 24 unmedicated, spontaneously breathing dogs. Intramuscular (i.m.) injections of meperidine, 2.75 mg/kg, 5.5 mg/kg and 11.0 mg/kg reduced the minimal alveolar concentration (MAC) of halothane required for anaesthesia. The magnitude and duration of MAC depression were dose related. Plasma meperidine concentrations following an i.m. injection of 2.75 mg/kg were lower in the awake, unsedated dogs than in the dogs anaesthetized with halothane.Entities:
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Year: 1977 PMID： 890559 DOI： 10.1007/bf03005450
Source DB: PubMed Journal: Can Anaesth Soc J ISSN： 0008-2856