Literature DB >> 8904179

Role of tissue factor and factor VIIa in the coagulant and inflammatory response to LD100 Escherichia coli in the baboon.

F B Taylor1.   

Abstract

Anti-tissue factor antibody and active site-inhibited factor VIIa inhibit both the disseminated intravascular coagulant response to LD100 Escherichia coli and its lethal inflammatory effects. In contrast, active site inhibited factor Xa while completely inhibiting disseminated intravascular coagulant does not protect baboons from LD100 E. coli. This review examines the role of tissue factor and factor VIIa in initiating the disseminated intravascular coagulant response and in amplifying the inflammatory response.

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Year:  1996        PMID： 8904179     DOI： 10.1159/000217246

Source DB:  PubMed          Journal:  Haemostasis        ISSN： 0301-0147


  6 in total

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Review 5.  Tissue factor: a key molecule in hemostatic and nonhemostatic systems.

Authors:  James H Morrissey
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  6 in total

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