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Literature DB >> 890326

Treatment of liposclerosis of the leg by fibrinolytic enhancement: a preliminary report.

N L Browse, P E Jarrett, M Morland, K Burnand.

Abstract

Fourteen patients with longstanding lipodermatosclerosis of their lower legs, secondary to venous disease in 11, were treated for three months with stanozolol, a drug that enhances fibrinolytic activity. No other treatment was given and no change made in existing treatment. All the patients improved. Two were cured in three months, three were able to stop treatment in the next three to 11 months, and the other nine continued to improve. Fibrinolytic enhancement, with stanozolol, seems to be a worthwhile addition to the treatment of venous liposclerosis and deserves further study.

Entities: Chemical Disease Species

Mesh：

Substances：
Stanozolol

Year: 1977 PMID： 890326 PMCID： PMC1631172 DOI： 10.1136/bmj.2.6084.434

Source DB: PubMed Journal: Br Med J ISSN： 0007-1447

6 in total

1. Evidence of a diurnal fibrinolytic rhythm; with a simple method of measuring natural fibrinolysis.

Authors: G R FEARNLEY; G BALMFORTH; E FEARNLEY
Journal: Clin Sci Date: 1957-11 Impact factor: 6.124

2. The fibrin plate method for estimating fibrinolytic activity.

Authors: T ASTRUP; S MULLERTZ
Journal: Arch Biochem Biophys Date: 1952-10 Impact factor: 4.013

3. Proceedings: Extravascular fibrin deposition in response to venous hypertension-the cause of venous ulcers.

Authors: K G Burnand; G Clemenson; I Whimpster; N L Browse
Journal: Br J Surg Date: 1976-08 Impact factor: 6.939

4. Fibrinolytic enhancement by stanozolol: a double blind trial.

Authors: J F Davidson; M Lochhead; G A McDonald; G P McNicol
Journal: Br J Haematol Date: 1972-05 Impact factor: 6.998

5. Idiopathic recurrent superficial thrombophlebitis: treatment with fibrinolytic enhancement.

Authors: P E Jarrett; M Morland; N L Browse
Journal: Br Med J Date: 1977-04-09

6. Blood and vein-wall fibrinolytic activity in health and vascular disease.

Authors: N L Browse; L Gray; P E Jarrett; M Morland
Journal: Br Med J Date: 1977-02-19

6 in total

10 in total

Review 1. Leg ulceration in venous disease.

Authors: S K Shami; D A Shields; J H Scurr; P D Smith
Journal: Postgrad Med J Date: 1992-10 Impact factor: 2.401

Review 7. Management of leg ulcers.

Authors: P K Sarkar; S Ballantyne
Journal: Postgrad Med J Date: 2000-11 Impact factor: 2.401

Treatment of liposclerosis of the leg by fibrinolytic enhancement: a preliminary report.

1. Evidence of a diurnal fibrinolytic rhythm; with a simple method of measuring natural fibrinolysis.

2. The fibrin plate method for estimating fibrinolytic activity.

3. Proceedings: Extravascular fibrin deposition in response to venous hypertension-the cause of venous ulcers.

4. Fibrinolytic enhancement by stanozolol: a double blind trial.

5. Idiopathic recurrent superficial thrombophlebitis: treatment with fibrinolytic enhancement.

6. Blood and vein-wall fibrinolytic activity in health and vascular disease.

Review 1. Leg ulceration in venous disease.

2. A controlled study of stanozolol in primary Raynaud's phenomenon and systemic sclerosis.

3. The etiology of venous ulceration.

4. Venous ulceration.

5. Venous ulceration.

6. Pericapillary fibrin in the ulcer-bearing skin of the leg: the cause of lipodermatosclerosis and venous ulceration.

Review 7. Management of leg ulcers.

Review 8. Drug treatment of chronic venous insufficiency and venous ulceration: a review.

Review 9. Systemic sclerosis--a microvascular disorder?

10. Venous leg ulcer: Systemic therapy.