1996 diagnostic and classification criteria for the antiphospholipid/cofactors syndrome: a "mission impossible'?

Due to recent acquisitions, diagnostic criteria for the antiphospholipid/cofactors syndrome need to be improved. In the absence of a "common biological denominator", the best approach should be based on a scoring system mixing clinical and immunological items. APS might be composed of different biological subsets characterized by antibodies directed to various cofactors. Among clinical subsets, the categorization between "primary" and SLE-related APS may be difficult to achieve. Contrasting with the innumerable conditions associated with the presence of aPL, the diversity of "true" secondary APS should probably be restrained. Attempts at establishing correlations between clinical and biological APS subsets will require further studies.