Literature DB >> 8902629

Purification and properties of human D-3-hydroxyacyl-CoA dehydratase: medium-chain enoyl-CoA hydratase is D-3-hydroxyacyl-CoA dehydratase.

L L Jiang1, A Kobayashi, H Matsuura, H Fukushima, T Hashimoto.   

Abstract

Human medium-chain enoyl-CoA hydratase was purified from liver, because we noticed the presence of a high medium-chain enoyl-CoA hydratase activity in human skin fibroblasts catalyzed by an enzyme different from the known enzymes catalyzing the enoyl-CoA hydratase reaction. Two enzyme preparations were obtained. One of them, preparation I, consisted of 46-kDa polypeptide, and its molecular mass was estimated to be 86 kDa. The other, preparation II, consisted of a major 77-kDa polypeptide and minor smaller polypeptides including 46-kDa polypeptide. The molecular mass of preparation II was 154 kDa. Both enzyme preparations catalyzed reversible dehydration of medium-chain D-3-hydroxyacyl-CoA to 2-trans-enoyl-CoA, but did not react with L-3-hydroxyacyl-CoA. Catalytic properties and immunochemical reactivities of these enzyme preparations were nearly the same. The cross-reactive material to the antibody was confirmed to be in peroxisomes by immunohistochemical study of cultured human skin fibroblasts.

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Year:  1996        PMID： 8902629     DOI： 10.1093/oxfordjournals.jbchem.a021458

Source DB:  PubMed          Journal:  J Biochem        ISSN： 0021-924X            Impact factor:   3.387


  11 in total

Review 1.  Peroxisomal beta-oxidation enzymes.

Authors:  T Hashimoto
Journal:  Neurochem Res       Date:  1999-04       Impact factor: 3.996

2.  D-3-hydroxyacyl-CoA dehydratase/D-3-hydroxyacyl-CoA dehydrogenase bifunctional protein deficiency: a newly identified peroxisomal disorder.

Authors:  Y Suzuki; L L Jiang; M Souri; S Miyazawa; S Fukuda; Z Zhang; M Une; N Shimozawa; N Kondo; T Orii; T Hashimoto
Journal:  Am J Hum Genet       Date:  1997-11       Impact factor: 11.025

3.  Mutations in the DBP-deficiency protein HSD17B4 cause ovarian dysgenesis, hearing loss, and ataxia of Perrault Syndrome.

Authors:  Sarah B Pierce; Tom Walsh; Karen M Chisholm; Ming K Lee; Anne M Thornton; Agata Fiumara; John M Opitz; Ephrat Levy-Lahad; Rachel E Klevit; Mary-Claire King
Journal:  Am J Hum Genet       Date:  2010-07-30       Impact factor: 11.025

4.  Peroxisomal D-hydroxyacyl-CoA dehydrogenase deficiency: resolution of the enzyme defect and its molecular basis in bifunctional protein deficiency.

Authors:  E G van Grunsven; E van Berkel; L Ijlst; P Vreken; J B de Klerk; J Adamski; H Lemonde; P T Clayton; D A Cuebas; R J Wanders
Journal:  Proc Natl Acad Sci U S A       Date:  1998-03-03       Impact factor: 11.205

5.  Characterization of S-hexylglutathione-binding proteins of human hepatocellular carcinoma: separation of enoyl-CoA isomerase from an Alpha class glutathione transferase form.

Authors:  H Kajihara-Kano; M Hayakari; K Satoh; Y Tomioka; M Mizugaki; S Tsuchida
Journal:  Biochem J       Date:  1997-12-01       Impact factor: 3.857

6.  Identification of a substrate-binding site in a peroxisomal beta-oxidation enzyme by photoaffinity labeling with a novel palmitoyl derivative.

Authors:  Yoshinori Kashiwayama; Takenori Tomohiro; Kotomi Narita; Miyuki Suzumura; Tuomo Glumoff; J Kalervo Hiltunen; Paul P Van Veldhoven; Yasumaru Hatanaka; Tsuneo Imanaka
Journal:  J Biol Chem       Date:  2010-06-21       Impact factor: 5.157

7.  Peroxisomal beta-oxidation of polyunsaturated fatty acids in Saccharomyces cerevisiae: isocitrate dehydrogenase provides NADPH for reduction of double bonds at even positions.

Authors:  C W van Roermund; E H Hettema; A J Kal; M van den Berg; H F Tabak; R J Wanders
Journal:  EMBO J       Date:  1998-02-02       Impact factor: 11.598

8.  Mutational spectrum of D-bifunctional protein deficiency and structure-based genotype-phenotype analysis.

Authors:  Sacha Ferdinandusse; Mari S Ylianttila; Jolein Gloerich; M Kristian Koski; Wendy Oostheim; Hans R Waterham; J Kalervo Hiltunen; Ronald J A Wanders; Tuomo Glumoff
Journal:  Am J Hum Genet       Date:  2005-11-15       Impact factor: 11.025

9.  5-Hydroxydecanoate is metabolised in mitochondria and creates a rate-limiting bottleneck for beta-oxidation of fatty acids.

Authors:  Peter J Hanley; Stefan Dröse; Ulrich Brandt; Rachel A Lareau; Abir L Banerjee; D K Srivastava; Leonard J Banaszak; Joseph J Barycki; Paul P Van Veldhoven; Jürgen Daut
Journal:  J Physiol       Date:  2004-10-28       Impact factor: 5.182

10.  Systematic investigation of lycopene effects in LNCaP cells by use of novel large-scale proteomic analysis software.

Authors:  Young Ah Goo; Zheng Li; Natasa Pajkovic; Scott Shaffer; Greg Taylor; Jinzhi Chen; David Campbell; Larry Arnstein; David R Goodlett; Richard B van Breemen
Journal:  Proteomics Clin Appl       Date:  2007-05-01       Impact factor: 3.494
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