Influence of Ukrain on the redox processes of hepatocytes.

In our in-vitro experiments on the addition of Ukrain into an incubation solution of intact rat liver-cell homogenate, it was indicated that the effect of Ukrain depends on the metabolic redox chain. The endogenous respiration rate which is supported by ionic solution of incubation only, with Ukrain addition submits to a 25% decline. At the same time Ukrain stimulates NADP-dependent oxidation. Since the oxygen consumption increase under Ukrain's influence is characteristic of the metabolic state 4 of Chance (1956), it could be explained as a protonophoric effect (6). The data obtained indicate a complex mechanism of Ukrain's influence on the processes basic for the living organism, the breakage of which always leads to the pathological changes.