| Literature DB >> 8899291 |
V Rusch1, J Mendelsohn, E Dmitrovsky.
Abstract
The epidermal growth factor receptor (EGFR) is detected on many non-haematopoietic tissues and is frequently overexpressed in human tumors. With its ligand, TGF-alpha, it forms a well-defined autocrine growth loop. Several clinical approaches, using EGFR as a therapeutic target, are being investigated, particularly monoclonal antibodies combined with chemotherapy, and pharmacological inhibition of downstream components of the EGFR signaling pathway.Entities:
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Year: 1996 PMID： 8899291 DOI： 10.1016/1359-6101(96)00016-0
Source DB: PubMed Journal: Cytokine Growth Factor Rev ISSN： 1359-6101 Impact factor: 7.638