| Literature DB >> 8898870 |
Abstract
The action of peroxynitrite on human erythrocytes and erythrocyte membranes was studied. Peroxynitrite (0.1-2 mM) induced a transient decrease of intracellular reduced glutathione, oxidized membrane protein -SH groups, initiated membrane lipid peroxidation and inactivated erythrocyte membrane acetylcholinesterase and ATPase activities. Membranes exposed to peroxynitrite showed aggregation and nitration of proteins and changes in protein organization detectable with a maleimide spin label.Entities:
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Year: 1996 PMID： 8898870 DOI： 10.1016/0304-4165(96)00052-9
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002