Literature DB >> 8897271

Design and evaluation of two-phase partition-dissolution method and its use in evaluating artemisinin tablets.

N T Hoa1, R Kinget.   

Abstract

A method is described for the assessment of the dissolution behavior of solid dosage forms with a high content of a very water insoluble drug. In this method the dissolved drug is continuously extracted from the aqueous dissolution medium into an organic phase. The reported data on the dissolution of artemisinin show that this method guarantees sink conditions in the aqueous dissolution medium during the total duration of the experiment.

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Year:  1996        PMID： 8897271     DOI： 10.1021/js960115u

Source DB:  PubMed          Journal:  J Pharm Sci        ISSN： 0022-3549            Impact factor:   3.534


  4 in total

1.  The Biopharmaceutics Classification System: subclasses for in vivo predictive dissolution (IPD) methodology and IVIVC.

Authors:  Yasuhiro Tsume; Deanna M Mudie; Peter Langguth; Greg E Amidon; Gordon L Amidon
Journal:  Eur J Pharm Sci       Date:  2014-01-28       Impact factor: 4.384

2.  Mechanistic analysis of solute transport in an in vitro physiological two-phase dissolution apparatus.

Authors:  Deanna M Mudie; Yi Shi; Haili Ping; Ping Gao; Gordon L Amidon; Gregory E Amidon
Journal:  Biopharm Drug Dispos       Date:  2012-09-04       Impact factor: 1.627

3.  Experiments and modeling of controlled release behavior of commercial and model polymer-drug formulations using dialysis membrane method.

Authors:  Alok Ranjan; Prateek K Jha
Journal:  Drug Deliv Transl Res       Date:  2020-04       Impact factor: 4.617

4.  On the Usefulness of Two Small-Scale In Vitro Setups in the Evaluation of Luminal Precipitation of Lipophilic Weak Bases in Early Formulation Development.

Authors:  Patrick J O'Dwyer; Georgios Imanidis; Karl J Box; Christos Reppas
Journal:  Pharmaceutics       Date:  2020-03-16       Impact factor: 6.321
  4 in total

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