Literature DB >> 8896196

Development of an antivenom against toxins of Lonomia obliqua caterpillars.

W D Da Silva1, C M Campos, L R Gonçalves, M C Sousa-e-Silva, H G Higashi, I K Yamagushi, E M Kelen.   

Abstract

Skin contact with caterpillars of Lonomia moths causes haemostatic disorders that may evolve into a haemorrhagic syndrome. Replacement therapy has been shown to exacerbate the clinical symptoms of this envenoming. In this study it is shown that horses immunized with a bristle extract of L. obliqua caterpillars produced IgG antibodies that completely neutralized, in vitro, the toxin(s) responsible for the blood incoagulability observed in rats. This antivenom offers the possibility of specific treatment for envenoming caused by contact with caterpillars of Lonomia moths.

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Year:  1996        PMID： 8896196     DOI： 10.1016/0041-0101(96)00052-9

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  6 in total

1.  Mechanisms of acute kidney injury induced by experimental Lonomia obliqua envenomation.

Authors:  Markus Berger; Lucélia Santi; Walter O Beys-da-Silva; Fabrício Marcus Silva Oliveira; Marcelo Vidigal Caliari; John R Yates; Maria Aparecida Ribeiro Vieira; Jorge Almeida Guimarães
Journal:  Arch Toxicol       Date:  2014-05-06       Impact factor: 5.153

2.  Accident involving a 2-year-old child and Lonomia obliqua venom: clinical and coagulation abnormalities.

Authors:  Daniela Nasu Monteiro Medeiros; Hélida Conceição Cavalcante Torres; Eduarto Juan Troster
Journal:  Rev Bras Hematol Hemoter       Date:  2014-10-01

3.  Hemostatic disorders induced by skin contact with Lonomia obliqua (Lepidoptera, Saturniidae) caterpillars.

Authors:  Ida Sigueko Sano-Martins; Alaour Candida Duarte; Belsy Guerrero; Roberto Henrique Pinto Moraes; Elvino José Guardão Barros; Carmen Luisa Arocha-Piñango
Journal:  Rev Inst Med Trop Sao Paulo       Date:  2017-04-20       Impact factor: 1.846

4.  Effectiveness of Lonomia antivenom in recovery from the coagulopathy induced by Lonomia orientoandensis and Lonomia casanarensis caterpillars in rats.

Authors:  Ida S Sano-Martins; Camila González; Isabelle Valle Anjos; Juana Díaz; Luis Roberto C Gonçalves
Journal:  PLoS Negl Trop Dis       Date:  2018-08-16

5.  In vitro antitumor, pro-inflammatory, and pro-coagulant activities of Megalopyge opercularis J.E. Smith hemolymph and spine venom.

Authors:  Alonso A Orozco-Flores; José A Valadez-Lira; Karina E Covarrubias-Cárdenas; José J Pérez-Trujillo; Ricardo Gomez-Flores; Diana Caballero-Hernández; Reyes Tamez-Guerra; Cristina Rodríguez-Padilla; Patricia Tamez-Guerra
Journal:  Sci Rep       Date:  2020-10-27       Impact factor: 4.379

Review 6.  Lonomia obliqua Envenoming and Innovative Research.

Authors:  Miryam Paola Alvarez-Flores; Renata Nascimento Gomes; Dilza Trevisan-Silva; Douglas Souza Oliveira; Isabel de Fátima Correia Batista; Marcus Vinicius Buri; Angela Maria Alvarez; Carlos DeOcesano-Pereira; Marcelo Medina de Souza; Ana Marisa Chudzinski-Tavassi
Journal:  Toxins (Basel)       Date:  2021-11-23       Impact factor: 4.546
  6 in total

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