Literature DB >> 8894503

The importance of nonspecific binding in in vitro matrices, its impact on enzyme kinetic studies of drug metabolism reactions, and implications for in vitro-in vivo correlations.

R S Obach.   

Abstract

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Year:  1996        PMID： 8894503

Source DB:  PubMed          Journal:  Drug Metab Dispos        ISSN： 0090-9556            Impact factor:   3.922


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  14 in total

Review 1.  Effects of the antifungal agents on oxidative drug metabolism: clinical relevance.

Authors:  K Venkatakrishnan; L L von Moltke; D J Greenblatt
Journal:  Clin Pharmacokinet       Date:  2000-02       Impact factor: 6.447

2.  A novel strategy for physiologically based predictions of human pharmacokinetics.

Authors:  Hannah M Jones; Neil Parrott; Karin Jorga; Thierry Lavé
Journal:  Clin Pharmacokinet       Date:  2006       Impact factor: 6.447

3.  Quantitative characterization of binding of small molecules to extracellular matrix.

Authors:  Yufen Zhang; Viera Lukacova; Katie Reindl; Stefan Balaz
Journal:  J Biochem Biophys Methods       Date:  2006-02-17

Review 4.  Prediction of hepatic clearance in human from in vitro data for successful drug development.

Authors:  Masato Chiba; Yasuyuki Ishii; Yuichi Sugiyama
Journal:  AAPS J       Date:  2009-04-30       Impact factor: 4.009

Review 5.  Modeling kinetics of subcellular disposition of chemicals.

Authors:  Stefan Balaz
Journal:  Chem Rev       Date:  2009-05       Impact factor: 60.622

6.  Determination of intracellular unbound concentrations and subcellular localization of drugs in rat sandwich-cultured hepatocytes compared with liver tissue.

Authors:  Nathan D Pfeifer; Kevin B Harris; Grace Zhixia Yan; Kim L R Brouwer
Journal:  Drug Metab Dispos       Date:  2013-08-29       Impact factor: 3.922

7.  Determination of the rate-limiting step in the hepatic elimination of YM796 by isolated rat hepatocytes.

Authors:  T Iwatsubo; H Suzuki; Y Sugiyama
Journal:  Pharm Res       Date:  1999-01       Impact factor: 4.200

Review 8.  Spatially Resolved Analytical Chemistry in Intact, Living Tissues.

Authors:  Maura C Belanger; Parastoo Anbaei; Austin F Dunn; Andrew W L Kinman; Rebecca R Pompano
Journal:  Anal Chem       Date:  2020-11-17       Impact factor: 6.986

9.  Inhibition of in vitro metabolism of simvastatin by itraconazole in humans and prediction of in vivo drug-drug interactions.

Authors:  M Ishigam; M Uchiyama; T Kondo; H Iwabuchi; S Inoue; W Takasaki; T Ikeda; T Komai; K Ito; Y Sugiyama
Journal:  Pharm Res       Date:  2001-05       Impact factor: 4.200

10.  Nonspecific binding of drugs to human liver microsomes.

Authors:  J A McLure; J O Miners; D J Birkett
Journal:  Br J Clin Pharmacol       Date:  2000-05       Impact factor: 4.335
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