Literature DB >> 8892066

Mitochondrial DNA levels in the brain of HIV-positive patients after zidovudine therapy.

F D Davison1, B J Sweeney, F Scaravilli.   

Abstract

Previous studies have shown that the antiviral nucleoside analogue zidovudine (AZT) depletes levels of mitochondrial DNA (mtDNA) in muscle of patients on long-term therapy. In this study we found that in a similar group of eight HIV-positive patients receiving AZT there was no depletion of brain mtDNA. This finding suggests that AZT-related mtDNA depletion is not a contributing factor in the HIV encephalopathy that occurs in a proportion of HIV-positive patients receiving this antiviral agent.

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Year:  1996        PMID： 8892066     DOI： 10.1007/bf00878661

Source DB:  PubMed          Journal:  J Neurol        ISSN： 0340-5354            Impact factor:   4.849


  16 in total

1.  Neuropathological evidence that zidovudine reduces incidence of HIV infection of brain.

Authors:  F Gray; C Geny; E Dournon; F Fenelon; F Lionnet; R Gherardi
Journal:  Lancet       Date:  1991-04-06       Impact factor: 79.321

2.  Apparent turnover of mitochondrial deoxyribonucleic acid and mitochondrial phospholipids in the tissues of the rat.

Authors:  N J Gross; G S Getz; M Rabinowitz
Journal:  J Biol Chem       Date:  1969-03-25       Impact factor: 5.157

3.  Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy.

Authors:  E Arnaudo; M Dalakas; S Shanske; C T Moraes; S DiMauro; E A Schon
Journal:  Lancet       Date:  1991-03-02       Impact factor: 79.321

4.  PCR detection of HIV proviral DNA (gag) in the brains of patients with AIDS: comparison between results using fresh frozen and paraffin wax embedded specimens.

Authors:  S F An; A Ciardi; F Scaravilli
Journal:  J Clin Pathol       Date:  1994-11       Impact factor: 3.411

5.  Synergistic inhibition of AZT-resistant HIV by AZT combined with poly(I):poly(C12U), without synergistic toxicity to bone marrow progenitor cell elements.

Authors:  D Gillespie; H R Hubbell; W A Carter; P Midgette; W Elsasser; R Mullaney; D R Strayer
Journal:  In Vivo       Date:  1994 May-Jun       Impact factor: 2.155

6.  Zidovudine treatment of the AIDS dementia complex: results of a placebo-controlled trial. AIDS Clinical Trials Group.

Authors:  J J Sidtis; C Gatsonis; R W Price; E J Singer; A C Collier; D D Richman; M S Hirsch; F W Schaerf; M A Fischl; K Kieburtz
Journal:  Ann Neurol       Date:  1993-04       Impact factor: 10.422

7.  Effects of 3'-azido-3'-deoxythymidine metabolites on simian virus 40 origin-dependent replication and heteroduplex repair in HeLa cell extracts.

Authors:  K Bebenek; D C Thomas; J D Roberts; F Eckstein; T A Kunkel
Journal:  Mol Pharmacol       Date:  1993-01       Impact factor: 4.436

Review 8.  Mitochondrial encephalomyopathies.

Authors:  B Eymard; J J Hauw
Journal:  Curr Opin Neurol Neurosurg       Date:  1992-12

9.  Mitochondrial myopathy of childhood associated with depletion of mitochondrial DNA.

Authors:  H J Tritschler; F Andreetta; C T Moraes; E Bonilla; E Arnaudo; M J Danon; S Glass; B M Zelaya; E Vamos; N Telerman-Toppet
Journal:  Neurology       Date:  1992-01       Impact factor: 9.910

10.  Quantitative and sensitive northern blot hybridization using PCR-generated DNA probes labeled with digoxigenin by nick translation.

Authors:  M Sato; K Murao; M Mizobuchi; J Takahara
Journal:  Biotechniques       Date:  1993-11       Impact factor: 1.993
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  2 in total

Review 1.  Cerebral Vascular Toxicity of Antiretroviral Therapy.

Authors:  Luc Bertrand; Martina Velichkovska; Michal Toborek
Journal:  J Neuroimmune Pharmacol       Date:  2019-06-17       Impact factor: 4.147

2.  Long-term exposure of mice to nucleoside analogues disrupts mitochondrial DNA maintenance in cortical neurons.

Authors:  Yulin Zhang; Fengli Song; Ziyun Gao; Wei Ding; Luxin Qiao; Sufang Yang; Xi Chen; Ronghua Jin; Dexi Chen
Journal:  PLoS One       Date:  2014-01-20       Impact factor: 3.240
  2 in total

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