Literature DB >> 8891312

Cerebral uric acid increases following experimental traumatic brain injury in rat.

E C Tayag1, S N Nair, S Wahhab, C D Katsetos, J W Lighthall, J C Lehmann.   

Abstract

Following traumatic brain injury (TBI), cortical and thalamic areas were analyzed histologically and by high-performance liquid chromatography with electrochemical detection for uric acid at various survival times. Following TBI, cortical uric acid was elevated by ten-fold at 24 and 48 h, but not at 1 h post-TBI. Histological evidence of neurodegeneration was found not only in cortex but also in the anteroventral thalamus. These data suggest that as in stroke, uric acid measurements may be a convenient and sensitive method for measuring peroxidative status in TBI.

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Year:  1996        PMID： 8891312     DOI： 10.1016/0006-8993(96)00669-5

Source DB:  PubMed          Journal:  Brain Res        ISSN： 0006-8993            Impact factor:   3.252


  8 in total

1.  Different roles of radical scavengers--ascorbate and urate in the cerebrospinal fluid of amyotrophic lateral sclerosis patients.

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Journal:  Redox Rep       Date:  2010       Impact factor: 4.412

2.  Microdialytical monitoring of uric and ascorbic acids in the brains of patients after severe brain injury and during neurovascular surgery.

Authors:  H Langemann; T Feuerstein; A Mendelowitsch; O Gratzl
Journal:  J Neurol Neurosurg Psychiatry       Date:  2001-08       Impact factor: 10.154

3.  ABCG2 c.421C>A Is Associated with Outcomes after Severe Traumatic Brain Injury.

Authors:  Solomon M Adams; Yvette P Conley; Dianxu Ren; David O Okonkwo; Ava M Puccio; C Edward Dixon; Robert S B Clark; Patrick M Kochanek; Philip E Empey
Journal:  J Neurotrauma       Date:  2017-09-19       Impact factor: 5.269

4.  Association of Serum Uric Acid Level with the Severity of Brain Injury and Patient's Outcome in Severe Traumatic Brain Injury.

Authors:  Masoud Hatefi; Masoud Moghadas Dastjerdi; Bahareh Ghiasi; Asghar Rahmani
Journal:  J Clin Diagn Res       Date:  2016-12-01

Review 5.  Uric acid and xanthine oxidase: future therapeutic targets in the prevention of cardiovascular disease?

Authors:  Jesse Dawson; Matthew Walters
Journal:  Br J Clin Pharmacol       Date:  2006-12       Impact factor: 4.335

6.  Cerebrospinal fluid purinomics as a biomarker approach to predict outcome after severe traumatic brain injury.

Authors:  Nathan R Strogulski; Marco Antonio Stefani; Ana Elisa Böhmer; Gisele Hansel; Marcelo S Rodolphi; Afonso Kopczynski; Vitória G de Oliveira; Eduarda T Stefani; Juliana V Portela; André P Schmidt; Jean Pierre Oses; Douglas H Smith; Luis V Portela
Journal:  J Neurochem       Date:  2022-03-06       Impact factor: 5.546

7.  The potential for xanthine oxidase inhibition in the prevention and treatment of cardiovascular and cerebrovascular disease.

Authors:  Peter Higgins; Jesse Dawson; Matthew Walters
Journal:  Cardiovasc Psychiatry Neurol       Date:  2009-11-04

8.  Acute brain injury triggers MyD88-dependent, TLR2/4-independent inflammatory responses.

Authors:  Uwe Koedel; Ulrike Michaela Merbt; Caroline Schmidt; Barbara Angele; Bernadette Popp; Hermann Wagner; Hans-Walter Pfister; Carsten J Kirschning
Journal:  Am J Pathol       Date:  2007-07       Impact factor: 4.307
  8 in total

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