Generalised acanthosis nigricans with vitiligo.

We report on a 19-year-old woman with generalised acanthosis nigricans of the inherited type and concomitant vitiligo. Cutaneous velvety thickening of the skin with intensification of skin markings and progressive development of hyperpigmented papillomatous, verrucoid lesions in the body folds started to develop in early childhood. These hyperpigmentations were continuously replaced by a progressive vitiligo, finally leaving most of the acanthosis nigricans lesions completely depigmented. Generalised, pachyderma-like acanthosis nigricans with concomitant vitiligo is an association which to the best of our knowledge has not yet been described.