Literature DB >> 8889493

Protection against peroxynitrite-dependent tyrosine nitration and alpha 1-antiproteinase inactivation by ascorbic acid. A comparison with other biological antioxidants.

M Whiteman1, B Halliwell.   

Abstract

Peroxynitrite, formed by reaction of superoxide and nitric oxide, appears to be an important tissue-damaging species generated at sites of inflammation. In this paper, we compare the abilities of several biological antioxidants to protect against peroxynitrite-dependent inactivation of alpha 1-antiproteinase, and to inhibit tyrosine nitration upon addition of peroxynitrite. GSH and ascorbate protected efficiently in both systems. Uric acid inhibited tyrosine nitration but not alpha 1-antiproteinase inactivation. The possibility that ascorbic acid is an important scavenger of reactive nitrogen species in vivo is discussed.

Entities:  

Mesh：

Substances：

Year:  1996        PMID： 8889493     DOI： 10.3109/10715769609149052

Source DB:  PubMed          Journal:  Free Radic Res        ISSN： 1029-2470


  27 in total

1.  Protective effects of Asian green vegetables against oxidant induced cytotoxicity.

Authors:  Peter Rose; Choon Nam Ong; Matt Whiteman
Journal:  World J Gastroenterol       Date:  2005-12-28       Impact factor: 5.742

2.  Self-sufficient control of urate homeostasis in mice by a synthetic circuit.

Authors:  Christian Kemmer; Marc Gitzinger; Marie Daoud-El Baba; Valentin Djonov; Jörg Stelling; Martin Fussenegger
Journal:  Nat Biotechnol       Date:  2010-03-28       Impact factor: 54.908

Review 3.  Ultraviolet radiation: cellular antioxidant response and the role of ocular aldehyde dehydrogenase enzymes.

Authors:  Satori A Marchitti; Ying Chen; David C Thompson; Vasilis Vasiliou
Journal:  Eye Contact Lens       Date:  2011-07       Impact factor: 2.018

4.  The in vitro manipulation of carbohydrate metabolism: a new strategy for deciphering the cellular defence mechanisms against nitric oxide attack.

Authors:  C Le Goffe; G Vallette; A Jarry; C Bou-Hanna; C L Laboisse
Journal:  Biochem J       Date:  1999-12-15       Impact factor: 3.857

5.  A critical role of gastric mucosal ascorbic acid in the progression of acute gastric mucosal lesions induced by compound 48/80 in rats.

Authors:  Yoshio Kamiya; Yoshiji Ohta; Yoichiro Imai; Tomiyasu Arisawa; Hiroshi Nakano
Journal:  World J Gastroenterol       Date:  2005-03-07       Impact factor: 5.742

6.  Threshold levels of extracellular l-arginine that trigger NOS-mediated ROS/RNS production in cardiac ventricular myocytes.

Authors:  Jayalakshmi Ramachandran; R Daniel Peluffo
Journal:  Am J Physiol Cell Physiol       Date:  2016-11-30       Impact factor: 4.249

7.  A study on the role of nitric oxide and iron in 3-morpholino-sydnonimine-induced increases in dopamine release in the striatum of freely moving rats.

Authors:  P A Serra; G Rocchitta; G Esposito; M R Delogu; R Migheli; E Miele; M S Desole; M Miele
Journal:  Br J Pharmacol       Date:  2001-09       Impact factor: 8.739

Review 8.  Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems.

Authors:  Jian-Ming Lü; Peter H Lin; Qizhi Yao; Changyi Chen
Journal:  J Cell Mol Med       Date:  2009-09-14       Impact factor: 5.310

Review 9.  Antioxidant defenses in the ocular surface.

Authors:  Ying Chen; Gaurav Mehta; Vasilis Vasiliou
Journal:  Ocul Surf       Date:  2009-10       Impact factor: 5.033

10.  Experimental diabetes causes breakdown of the blood-retina barrier by a mechanism involving tyrosine nitration and increases in expression of vascular endothelial growth factor and urokinase plasminogen activator receptor.

Authors:  Azza B El-Remessy; M Ali Behzadian; Gamal Abou-Mohamed; Telina Franklin; Robert W Caldwell; Ruth B Caldwell
Journal:  Am J Pathol       Date:  2003-06       Impact factor: 4.307
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.